Multiple primary pulmonary meningioma: A case report and literature review

Abstract

Lung cancer has become a leading cause of cancer-related deaths. With the conventional use of low-dose spiral computed tomography (CT) in physical examinations, an increasing number of small pulmonary nodules are screened. However, primary pulmonary meningiomas (PPMs) are rarely reported. Here, we report the case of a 64-year-old woman who had a CT scan during physical examination, which revealed three ground-glass-like opacity pulmonary nodules in both lungs. The patient underwent video-assisted thoracoscopic wedge resection of the right upper and lower lobes. Paraffin sections revealed pulmonary meningothelial-like and collagenous nodules in the right upper and lower lobes which stained as follows: EMA+, VIM+, SMA-, S-100-, CD34-, STAT6-, Ki-67+ (2%), and CgA-. Primary pulmonary meningiomas (PPMs) were finally diagnosed. PPM is a kind of rare and benign tumor. Surgery can provide a precise pathological examination, and patients can achieve an excellent prognosis after surgical resection.

FIGURE 1

(a–c) The nodules located in the right upper/right lower/left lower lobes. (d) Hematoxylin and eosin (HE) staining showed many pulmonary meningothelial‐like nodules (400× magnification). (e) Immunohistochemical staining with epithelial membrane antigen (EMA) was positive (400× magnification). (f) Immunohistochemical staining with vimentin (VIM) was positive (400× magnification)