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. 2022 Sep;69(9):e29791.
doi: 10.1002/pbc.29791. Epub 2022 Jun 23.

Adolescent and parent perspectives on genomic sequencing to inform cancer care

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Adolescent and parent perspectives on genomic sequencing to inform cancer care

Laura K Sedig et al. Pediatr Blood Cancer. 2022 Sep.

Abstract

Next-generation sequencing offers opportunities for targeted cancer therapies and may identify pathogenic germline variants. Adolescents' perception of testing is not well understood. We surveyed 16 adolescents and 59 parents regarding motivations, attitudes, and knowledge related to paired tumor/germline sequencing. Participants generally had a good objective understanding of germline genetics and cancer risk, with parents scoring higher than adolescents. Nearly all participants were motivated by a desire to help other patients and to treat their child/themselves. Most adolescents reported involvement in the decision to enroll in the study. Study findings suggest important similarities and differences between parent and adolescent views.

Keywords: adolescents; cancer genetics; health behavior; pediatric oncology; precision medicine.

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References

REFERENCES

    1. Weathers S-PS, Gilbert MR. Towards personalized targeted therapeutics: an overview. Neurotherapeutics. 2017;14(2):256-264.
    1. Patterson SE, Liu R, Statz CM, Durkin D, Lakshminarayana A, Mockus SM. The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies. Hum Genomics. 2016;10(4):4.
    1. Shirdarreh M, Aziza O, Pezo RC, Jerzak KJ, Warner E. Patients' and oncologists' knowledge and expectations regarding tumor multigene next-generation sequencing: a narrative review. Oncologist. 2021;26(8):e1359-e1371.
    1. Fernandez CV, Gao J, Strahlendorf C, et al. Providing research results to participants: attitudes and needs of adolescents and parents of children with cancer. J Clin Oncol. 2009;27(6):878-883.
    1. Lewis C, Hammond J, Hill M, et al. Young people's understanding, attitudes and involvement in decision-making about genome sequencing for rare diseases: a qualitative study with participants in the UK 100,000 Genomes Project. Eur J Med Genet. 2020;63(11):104043.

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