A Narrative Review on the Collection and Use of Electronic Patient-Reported Outcomes in Cancer Survivorship Care with Emphasis on Symptom Monitoring

Corina J G van den Hurk¹, Floortje Mols^{1

2}, Manuela Eicher^{3

4}, Raymond J Chan⁵, Annemarie Becker⁶, Gijs Geleijnse¹, Iris Walraven⁷, Annemarie Coolbrandt^{8

9}, Maryam Lustberg^{10

11}, Galina Velikova¹², Andreas Charalambous^{13

14}, Bogda Koczwara¹⁵, Doris Howell¹⁶, Ethan M Basch¹⁷, Lonneke V van de Poll-Franse^{1

2

18}

Affiliations

¹ Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), 3511 DT Utrecht, The Netherlands.
² CoRPS-Center of Research on Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, 5037 AB Tilburg, The Netherlands.
³ Institute of Higher Education and Research in Health Care (IUFRS), Faculty of Biology and Medicine, University of Lausanne and Lausanne University Hospital, CH-1010 Lausanne, Switzerland.
⁴ Department of Oncology, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
⁵ Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia.
⁶ Amsterdam UMC, Department of Pulmonary Diseases, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.
⁷ Radboudumc, Department for Health Evidence, 6525 GA Nijmegen, The Netherlands.
⁸ Department of Oncology Nursing, University Hospitals Leuven, 3000 Leuven, Belgium.
⁹ Department of Public Health and Primary Care, Academic Center for Nursing and Midwifery, 3000 Leuven, Belgium.
¹⁰ Breast Medical Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.
¹¹ Breast Center at Smilow Cancer Hospital, New Haven, CT 06519, USA.
¹² Leeds Institute of Medical Research at St James's, University of Leeds and Leeds Cancer Centre, St James's University Hospital, Leeds LS9 7TF, UK.
¹³ Nursing Department, Cyprus University of Technology, Limassol 3036, Cyprus.
¹⁴ Department of Nursing Science, University of Turku, 00074 CGI Turku, Finland.
¹⁵ Flinders Medical Centre, Flinders University, Adelaide, SA 5042, Australia.
¹⁶ Princess Margaret Cancer Research Institute, University of Toronto, Toronto, ON M5G 2M9, Canada.
¹⁷ Lineberger Comprehensive Cancer Center, University of North Carolina Cancer Center, Chapel Hill, NC 27599, USA.
¹⁸ Department of Psychosocial Research, Division of Psychosocial Research & Epidemiology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

PMID: 35735458
PMCID: PMC9222072
DOI: 10.3390/curroncol29060349

Review

A Narrative Review on the Collection and Use of Electronic Patient-Reported Outcomes in Cancer Survivorship Care with Emphasis on Symptom Monitoring

Corina J G van den Hurk et al. Curr Oncol. 2022.

. 2022 Jun 17;29(6):4370-4385.

doi: 10.3390/curroncol29060349.

Authors

Affiliations

¹ Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), 3511 DT Utrecht, The Netherlands.
² CoRPS-Center of Research on Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, 5037 AB Tilburg, The Netherlands.
³ Institute of Higher Education and Research in Health Care (IUFRS), Faculty of Biology and Medicine, University of Lausanne and Lausanne University Hospital, CH-1010 Lausanne, Switzerland.
⁴ Department of Oncology, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
⁵ Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia.
⁶ Amsterdam UMC, Department of Pulmonary Diseases, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.
⁷ Radboudumc, Department for Health Evidence, 6525 GA Nijmegen, The Netherlands.
⁸ Department of Oncology Nursing, University Hospitals Leuven, 3000 Leuven, Belgium.
⁹ Department of Public Health and Primary Care, Academic Center for Nursing and Midwifery, 3000 Leuven, Belgium.
¹⁰ Breast Medical Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.
¹¹ Breast Center at Smilow Cancer Hospital, New Haven, CT 06519, USA.
¹² Leeds Institute of Medical Research at St James's, University of Leeds and Leeds Cancer Centre, St James's University Hospital, Leeds LS9 7TF, UK.
¹³ Nursing Department, Cyprus University of Technology, Limassol 3036, Cyprus.
¹⁴ Department of Nursing Science, University of Turku, 00074 CGI Turku, Finland.
¹⁵ Flinders Medical Centre, Flinders University, Adelaide, SA 5042, Australia.
¹⁶ Princess Margaret Cancer Research Institute, University of Toronto, Toronto, ON M5G 2M9, Canada.
¹⁷ Lineberger Comprehensive Cancer Center, University of North Carolina Cancer Center, Chapel Hill, NC 27599, USA.
¹⁸ Department of Psychosocial Research, Division of Psychosocial Research & Epidemiology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

PMID: 35735458
PMCID: PMC9222072
DOI: 10.3390/curroncol29060349

Abstract

Electronic patient-reported outcome (ePRO) applications promise great added value for improving symptom management and health-related quality of life. The aim of this narrative review is to describe the collection and use of ePROs for cancer survivorship care, with an emphasis on ePRO-symptom monitoring. It offers many different perspectives from research settings, while current implementation in routine care is ongoing. ePRO collection optimizes survivorship care by providing insight into the patients' well-being and prioritizing their unmet needs during the whole trajectory from diagnosis to end-of-life. ePRO-symptom monitoring can contribute to timely health risk detection and subsequently allow earlier intervention. Detection is optimized by automatically generated alerts that vary from simple to complex and multilayered. Using ePRO-symptoms during in-hospital consultation enhances the patients' conversation with the health care provider before making informed decisions about treatments, other interventions, or self-management. ePRO(-symptoms) entail specific implementation issues and complementary ethics considerations. The latter is due to privacy concerns, digital divide, and scarcity of adequately representative data for particular groups of patients.

Keywords: cancer; eHealth; electronic patient-reported outcomes; ethics; quality of care; quality of life; self-management; survivorship; symptoms.

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Conflict of interest statement

Author C.J.G.v.d.H. has received institutional implementation and research grants from AstraZeneca, Boehringer-Ingelheim, Bristol Myers Squibb, Ipsen and Merck. Author M.E. received institutional research grants from Kaiku Health, Bristol Myers Squibb and Roche and institutional fees as a Scientific Advisory Board Member/Consultant from Roche. Author G.V. reports personal fees from Roche, Eisai, Novartis, Seattle Genetics and Sanofi, and institutional grants from Breast Cancer Now, EORTC, Yorkshire Cancer Research, Pfizer and IQVIA, outside the submitted work. Author E.M.B. receives personal fees as a scientific advisor/consultant to the following entities that provide bio-medical services and could give the appearance of potentially influencing the work: AstraZeneca, Carevive Systems, Navigating Cancer, Resilience, N-Power, and Sivan Healthcare. Author D.H. receives personal fees as a Scientific Advisory Board Member/Consultant to Carevive Systems and institutional grants from Astra Zeneca. Author A.C.(Andreas Charalambous), has received speaker honoraria and consultant fees from AstraZeneca, Daichy Sankyo, SPCC, MSD and project grants from Takeda and Amgen. Author R.J.C. has received speaker honoraria from Dr Reddy’s Laboratory and Stratpharma. The remaining authors declare no conflicts of interest.

References

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A Narrative Review on the Collection and Use of Electronic Patient-Reported Outcomes in Cancer Survivorship Care with Emphasis on Symptom Monitoring

Affiliations

A Narrative Review on the Collection and Use of Electronic Patient-Reported Outcomes in Cancer Survivorship Care with Emphasis on Symptom Monitoring

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical