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Review
. 2022 Jun 4;9(6):245.
doi: 10.3390/bioengineering9060245.

Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells

Daria S Chulpanova  1 , Tamara V Pukhalskaia  1 , Albert A Rizvanov  1 , Valeriya V Solovyeva  1
Affiliations
Review

Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells

Daria S Chulpanova et al. Bioengineering (Basel). .

Abstract

Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape, and other important processes. However, the ability of EVs to induce the transformation of normal cells has hardly been investigated. This review discusses studies that describe the ability of tumor-cell-derived EVs to alter the metabolism and morphology of normal cells, causing changes associated with malignant transformation. Additionally, the horizontal transfer of oncogenes through EVs of tumor cells and the induction of epigenetic changes in normal cells, which leads to genomic instability and subsequent oncogenic transformation of normal cells, are also discussed.

Keywords: carcinogenesis; extracellular vesicles; tumor heterogeneity; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The influence of tumor-cell-derived extracellular vesicle on the metabolism, structure, and epigenetic profile of normal cells.
See this image and copyright information in PMC

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