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Review
. 2022 Jun 6;7(2):74.
doi: 10.3390/biomimetics7020074.

Biomimetic Implant Surfaces and Their Role in Biological Integration-A Concise Review

Mariana Brito Cruz  1 , Neusa Silva  2 , Joana Faria Marques  1 , António Mata  1   3 , Felipe Samuel Silva  4 , João Caramês  5
Affiliations
Review

Biomimetic Implant Surfaces and Their Role in Biological Integration-A Concise Review

Mariana Brito Cruz et al. Biomimetics (Basel). .

Abstract

Background: The increased use of dental implants in oral rehabilitation has been followed by the development of new biomaterials as well as improvements in the performance of biomaterials already in use. This triggers the need for appropriate analytical approaches to assess the biological and, ultimately, clinical benefits of these approaches.

Aims: To address the role of physical, chemical, mechanical, and biological characteristics in order to determine the critical parameters to improve biological responses and the long-term effectiveness of dental implant surfaces.

Data sources and methods: Web of Science, MEDLINE and Lilacs databases were searched for the last 30 years in English, Spanish and Portuguese idioms.

Results: Chemical composition, wettability, roughness, and topography of dental implant surfaces have all been linked to biological regulation in cell interactions, osseointegration, bone tissue and peri-implant mucosa preservation.

Conclusion: Techniques involving subtractive and additive methods, especially those involving laser treatment or embedding of bioactive nanoparticles, have demonstrated promising results. However, the literature is heterogeneous regarding study design and methodology, which limits comparisons between studies and the definition of the critical determinants of optimal cell response.

Keywords: biomimetic; dental implants; dentistry; implant surface; oral rehabilitation; oral surgery; osseointegration.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic image of the most relevant biomimetic surface modification strategies.
See this image and copyright information in PMC

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