Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 23;15(1):226.
doi: 10.1186/s13071-022-05342-3.

Vector competence of Anopheles quadrimaculatus and Aedes albopictus for genetically distinct Jamestown Canyon virus strains circulating in the Northeast United States

Constentin Dieme  1   2 , Laura D Kramer  3   4 , Alexander T Ciota  3   4
Affiliations

Vector competence of Anopheles quadrimaculatus and Aedes albopictus for genetically distinct Jamestown Canyon virus strains circulating in the Northeast United States

Constentin Dieme et al. Parasit Vectors. .

Abstract

Background: Jamestown Canyon virus (JCV; Peribunyaviridae, Orthobunyavirus) is a mosquito-borne pathogen belonging to the California serogroup. The virus is endemic in North America and increasingly recognized as a public health concern. In this study, we determined the vector competence of Anopheles (An.) quadrimaculatus and Aedes (Ae.) albopictus for five JCV strains belonging to the two lineages circulating in the Northeast.

Methods: An. quadrimaculatus and Ae. albopictus were fed blood meals containing two lineage A strains and three lineage B strains. Vector competence of both mosquito species was evaluated at 7- and 14-days post-feeding (dpf) by testing for virus presence in bodies, legs, and saliva.

Results: Our results demonstrated that Ae. albopictus mosquitoes are a competent vector for both lineages, with similar transmission levels for all strains tested. Variable levels of infection (46-83%) and dissemination (17-38%) were measured in An. quadrimaculatus, yet no transmission was detected for the five JCV strains evaluated.

Conclusions: Our results demonstrate that establishment of Ae. albopictus in the Northeast could increase the risk of JCV but suggest An. quadrimaculatus are not a competent vector for JCV.

Keywords: Aedes albopictus; Anopheles quadrimaculatus; Jamestown Canyon virus; Vector competence.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Similar articles

See all similar articles

Cited by

References

    1. Webster D, Dimitrova K, Holloway K, Makowski K, Safronetz D, Drebot MA. California serogroup virus infection associated with encephalitis and cognitive decline, Canada, 2015. Emerg Infect Dis. 2017;23:1423–1424. doi: 10.3201/eid2308.170239. - DOI - PMC - PubMed
    1. Kinsella CM, Paras ML, Smole S, Mehta S, Ganesh V, Chen LH, et al. Jamestown Canyon virus in Massachusetts: clinical case series and vector screening. Emerg Microbes Infect. 2020;9:903–912. doi: 10.1080/22221751.2020.1756697. - DOI - PMC - PubMed
    1. Bennett RS, Nelson JT, Gresko AK, Murphy BR, Whitehead SS, Andreadis TG, et al. The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys. Virol J. 2011 doi: 10.1186/1743-422X-8-136. - DOI - PMC - PubMed
    1. Armstrong PM, Andreadis TG. Genetic relationships of Jamestown Canyon virus strains infecting mosquitoes collected in Connecticut. Am J Trop Med Hyg. 2007;77:1157–1162. doi: 10.4269/ajtmh.2007.77.1157. - DOI - PubMed
    1. Solomon IH, Ganesh VS, Yu G, Deng XD, Wilson MR, Miller S, et al. Fatal case of chronic Jamestown Canyon virus encephalitis diagnosed by metagenomic sequencing in patient receiving rituximab. Emerg Infect Dis. 2021;27:238–242. doi: 10.3201/eid2701.203448. - DOI - PMC - PubMed

LinkOut - more resources