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Review
. 2022 Jun 20;14(12):3030.
doi: 10.3390/cancers14123030.

Heterogeneity in Melanoma

Mei Fong Ng  1   2 , Jacinta L Simmons  1   2   3 , Glen M Boyle  1   2   3
Affiliations
Review

Heterogeneity in Melanoma

Mei Fong Ng et al. Cancers (Basel). .

Abstract

There is growing evidence that tumour heterogeneity has an imperative role in cancer development, evolution and resistance to therapy. Continuing advancements in biomedical research enable tumour heterogeneity to be observed and studied more critically. As one of the most heterogeneous human cancers, melanoma displays a high level of biological complexity during disease progression. However, much is still unknown regarding melanoma tumour heterogeneity, as well as the role it plays in disease progression and treatment response. This review aims to provide a concise summary of the importance of tumour heterogeneity in melanoma.

Keywords: intertumoural heterogeneity; intratumoural heterogeneity; melanoma; resistance; tumour heterogeneity.

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Conflict of interest statement

The authors declare no conflict of interest relating to the current manuscript.

Figures

Figure 1
Figure 1
Melanoma heterogeneity. (A) Intertumoural heterogeneity refers to differences between lesions in a patient, while (B) intratumoural heterogeneity describes the differences between cells or subpopulations of cells within a tumour. Advancement in technology has revealed (C) different cell states in melanoma tumours.
See this image and copyright information in PMC

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