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Editorial
. 2022 May 30;12(6):763.
doi: 10.3390/biom12060763.

Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium

Freeborn Rwere  1 , Xuan Yu  1 , Che-Hong Chen  2 , Eric R Gross  1
Affiliations
Editorial

Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium

Freeborn Rwere et al. Biomolecules. .

Abstract

The discovery of aldehydes dates back to 1774 when Carl Wilhelm Scheele synthesized acetaldehyde [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Exogenous and endogenous aldehydes cause DNA and protein adduct formations. (A) Formation of N2-etheno-2′-deoxyguanosine DNA adduct from deoxyguanosine and α,β-unsaturated aldehydes as products of lipid peroxidation. (B) Formation of a 4-hydroxynonenal (4-HNE) protein adduct from the reaction between 4-HNE and a cysteine residue. In addition to cysteine adducts, 4-HNE protein adducts can also form on histidine or lysine amino acids.
Figure 2
Figure 2
The 5th annual international ALDH2 research symposium on human disease and public health. Group photo on day one of the event.
See this image and copyright information in PMC

References

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