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. 2022 May 27;12(6):1334.
doi: 10.3390/diagnostics12061334.

The Maternal-Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study

Huanrong Li  1   2 , Meilu Lyu  1   2 , Ruqian Zhao  1   2 , Yuqin Zang  1   2 , Pengzhu Huang  1   2 , Jie Li  1   2 , Ye Yan  1   2 , Yingmei Wang  1   2 , Zengyan Li  1   2 , Cha Han  1   2 , Fengxia Xue  1   2
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The Maternal-Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study

Huanrong Li et al. Diagnostics (Basel). .

Abstract

Objective: This study aimed to investigate the maternal−neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal−neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187−2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (p < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal−neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART.

Keywords: assisted reproductive technology; outcomes; preeclampsia; twin pregnancies.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Forest plot showing risk factors for preeclampsia in twin pregnancies. Abbreviations: AOR, adjusted odds ratio; 95% CI, 95% confidence intervals; ART, assisted reproductive technology; PCOS, polycystic ovary syndrome; GDM, gestational diabetes mellitus. We adjusted for years, maternal age, gravidity, parity, abortion, PCOS, chorionicity, GDM, hyperthyroidism, and hypothyroidism.
Figure 2
Figure 2
Hypertension disorders in ART and non-ART group. * p < 0.05 was considered significant.
See this image and copyright information in PMC

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