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. 2022 Jun 19;11(6):935.
doi: 10.3390/biology11060935.

Oxidative Stress Biomarkers and Quality of Life Are Contributing Factors of Muscle Pain and Lean Body Mass in Patients with Fibromyalgia

Jousielle Márcia Dos Santos  1   2 , Ana Cristina Rodrigues Lacerda  1   2   3 , Vanessa Gonçalves César Ribeiro  1 , Pedro Henrique Scheidt Figueiredo  2 , Sueli Ferreira Fonseca  1 , Vanessa Kelly da Silva Lage  1 , Henrique Silveira Costa  2 , Vanessa Pereira Lima  2 , Borja Sañudo  4 , Mário Bernardo-Filho  5 , Danúbia da Cunha de Sá Caputo  5 , Vanessa Amaral Mendonça  1   2   3 , Redha Taiar  6
Affiliations

Oxidative Stress Biomarkers and Quality of Life Are Contributing Factors of Muscle Pain and Lean Body Mass in Patients with Fibromyalgia

Jousielle Márcia Dos Santos et al. Biology (Basel). .

Abstract

(1) The evidence points to an increase in oxygen reactive species as one of the possible causes of fibromyalgia (FM). In addition, it is plausible that an imbalance in redox markers can be associated with pain amplification and dynapenia in FM patients. The aim of our study was to investigate possible factors associated with muscle pain and lean body mass in FM patients. (2) Methods: This was a quantitative, exploratory and cross-sectional study of 47 patients with FM (53.45 + 7.32 years). We evaluated self-perceptions of muscle pain, lean body mass, body composition, quality of life, sleep quality, depression index, muscle performance and oxidative stress biomarkers. (3) Results: We observed that lower blood levels of antioxidants and poor quality of life explained 21% of the greater muscle pain. In addition, high blood levels of oxidative stress, worse muscle performance and poor quality of life explained 27% of the lower lean mass in patients with FM. (4) Conclusions: Larger amounts of lipid peroxidation and reductions in antioxidant levels, in addition to lower muscle performance and poor life quality, are possible independent contributors to greater muscle pain and lower lean body mass in FM patients.

Keywords: TBARS; fibromyalgia; lean body mass; muscle pain; oxidative stress; quality of life; superoxide dismutase.

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Conflict of interest statement

The authors declare no conflict of interest.

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