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Review
. 2022 Jun 16;11(12):3458.
doi: 10.3390/jcm11123458.

Obstructive Sleep Apnea in Heart Failure: Current Knowledge and Future Directions

Shahrokh Javaheri  1   2   3 , Sogol Javaheri  4
Affiliations
Review

Obstructive Sleep Apnea in Heart Failure: Current Knowledge and Future Directions

Shahrokh Javaheri et al. J Clin Med. .

Abstract

Obstructive sleep apnea (OSA) is highly prevalent among patients with asymptomatic left ventricular systolic and diastolic dysfunction and congestive heart failure, and if untreated may contribute to the clinical progression of heart failure (HF). Given the health and economic burden of HF, identifying potential modifiable risk factors such as OSA and whether appropriate treatment improves outcomes is of critical importance. Identifying the subgroups of patients with OSA and HF who would benefit most from OSA treatment is another important point. This focused review surveys current knowledge of OSA and HF in order to provide: (1) a better understanding of the pathophysiologic mechanisms that may increase morbidity among individuals with HF and comorbid OSA, (2) a summary of current observational data and small randomized trials, (3) an understanding of the limitations of current larger randomized controlled trials, and (4) future needs to more accurately determine the efficacy of OSA treatment among individuals with HF.

Keywords: continuous positive airway pressure; heart failure; obstructive sleep apnea.

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Conflict of interest statement

Sogol Javaheri is a consultant for Jazz Pharmaceuticals and receives grant funding from Zoll Medical. Shahrokh Javaheri has advised Jazz Pharmaceuticals, Fisher Pykel and Harmony Biosciences. He is a consultant for Zoll Medical.

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