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. 2022 May 27;12(6):884.
doi: 10.3390/jpm12060884.

Impaired Interhemispheric Synchrony in Parkinson's Disease with Fatigue

Yong-Sheng Yuan  1 , Min Ji  1 , Cai-Ting Gan  1 , Hui-Min Sun  1 , Li-Na Wang  1 , Ke-Zhong Zhang  1
Affiliations

Impaired Interhemispheric Synchrony in Parkinson's Disease with Fatigue

Yong-Sheng Yuan et al. J Pers Med. .

Abstract

The characteristics of interhemispheric resting-state functional connectivity (FC) in Parkinson's disease (PD) with fatigue remain unclear; therefore, we aimed to explore the changes in interhemispheric FC in PD patients with fatigue. Sixteen PD patients with fatigue (PDF), 16 PD patients without fatigue (PDNF) and 15 matched healthy controls (HCs) were enrolled in the retrospective cross-sectional study. We used voxel-mirrored homotopic connectivity (VMHC) to analyze the resting-state functional magnetic resonance imaging (fMRI) data of these subjects. Compared to PDNF, PDF patients had decreased VMHC values in the supramarginal gyri (SMG). Furthermore, the mean VMHC values of the SMG were negatively correlated with the mean fatigue severity scale (FSS/9) scores (r = -0.754, p = 0.001). Compared to HCs, PDF patients had decreased VMHC in the SMG and in the opercular parts of the inferior frontal gyri (IFG operc). The VMHC values in the IFG operc and middle frontal gyri (MFG) were notably decreased in PDNF patients compared with HCs. Our findings suggest that the reduced VMHC values within the bilateral SMG may be the unique imaging features of fatigue in PD, and may illuminate the neural mechanisms of fatigue in PD.

Keywords: Parkinson’s disease; fatigue; functional magnetic resonance imaging; supramarginal gyri; voxel-mirrored homotopic connectivity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flow diagram. MRI: magnetic resonance imaging.
Figure 2
Figure 2
Statistical maps showing VMHC differences in different brain regions between three groups. The results were corrected by AlphaSim (with a combined threshold of p < 0.01). (A) Differences between PDF patients and PDNF patients; (B) differences between PDF patients and HC group; (C) differences between PDNF patients and HC group. Abbreviations: VMHC: voxel-mirrored homotopic connectivity, HCs: healthy controls, PDF: Parkinson’s disease with fatigue, PDNF: Parkinson’s disease without fatigue, L: left, R: right.
Figure 3
Figure 3
Correlations between VMHC values in SMG and FSS/9 scores within the PDF patients. Scatterplots demonstrated that there was a significant negative correlation between the mean VMHC values in the SMG (r = −0.754, p = 0.001) and FSS/9 scores in PDF patients. Abbreviations: VMHC: voxel-mirrored homotopic connectivity; FSS: fatigue severity scale; SMG: supramarginal gyrus; PDF: Parkinson’s disease with fatigue.
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