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. 2022 May 27;12(6):801.
doi: 10.3390/life12060801.

Ciclopirox Hydroxypropyl Chitosan (CPX-HPCH) Nail Lacquer and Breathable Cosmetic Nail Polish: In Vitro Evaluation of Drug Transungual Permeation Following the Combined Application

Daniela Monti  1   2 , Silvia Tampucci  1   2 , Valentina Paganini  1 , Susi Burgalassi  1   2 , Patrizia Chetoni  1   2 , Jordi Galván  3 , Francesco Celandroni  4 , Emilia Ghelardi  4
Affiliations

Ciclopirox Hydroxypropyl Chitosan (CPX-HPCH) Nail Lacquer and Breathable Cosmetic Nail Polish: In Vitro Evaluation of Drug Transungual Permeation Following the Combined Application

Daniela Monti et al. Life (Basel). .

Abstract

Background: Onychomycosis produces nail chromatic alterations that lead patients to mask them with cosmetic enamels. Objectives: Evaluate drug transungual permeation and antimycotic activity against selected strains after application of CPX-HPCH nail lacquer (NL) on the nail pre-covered with breathable cosmetic polish.

Methods: CPX transungual permeation after applying CPX-HPCH NL once or twice a day on bovine hoof membranes pre-covered with a breathable cosmetic nail polish was compared to that obtained applying CPX-HPCH NL directly on the membrane. The relevant experimental permeates underwent an in vitro susceptibility test.

Results: After CPX-HPCH NL application once a day, the drug transungual flux in the presence of cosmetic product tended to decrease while maintaining the antifungal activity. Two daily applications of CPX-HPCH NL on the membrane pre-covered with cosmetic polish exhibited the same permeation profile as daily application of the medicated lacquer directly on the nail as well as the same microbiological activity.

Conclusions: The breathable cosmetic nail polish can be applied on the nail affected by onychomycosis in association with CPX-HPCH NL to mask the imperfections. The application of CPX-HPCH NL twice a day appears to be a good solution to obtain the same results as for a daily application without the presence of the cosmetic layer.

Keywords: antimycotic activity; bovine hoof membranes; breathable cosmetic polish; ciclopirox; nail lacquer; onychomycosis; transungual permeation.

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Conflict of interest statement

Jordi Galván is Global Medical Lead at Almirall S.A.; all the other authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Bovine hoof membranes before (A) and after (B) treatment with commercial breathable cosmetic nail polish (red color).
Figure 2
Figure 2
Permeation plot of CPX through bovine hoof membranes after application once a day of CPX-HPCH nail lacquer on the nail, pre-covered or not with commercial breathable cosmetic nail polish, by using Type A protocol.
Figure 3
Figure 3
Permeation plot of CPX through bovine hoof membranes protocol after application twice a day of CPX-HPCH NL on the nail pre-covered with commercial breathable cosmetic nail polish compared to the application of CPX-HPCH NL once a day directly on the nail by using Type B protocol.
See this image and copyright information in PMC

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