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. 2022 May 26;58(6):711.
doi: 10.3390/medicina58060711.

KLF10 Functions as an Independent Prognosis Factor for Gastric Cancer

Yueh-Min Lin  1   2 , Kun-Tu Yeh  1   2   3 , Chung-Min Yeh  1 , Maw-Soan Soon  4   5   6 , Li-Sung Hsu  7   8
Affiliations

KLF10 Functions as an Independent Prognosis Factor for Gastric Cancer

Yueh-Min Lin et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Krűppel-like factor 10 (KLF10) participates in the tumorigenesis of several human cancers by binding to the GC-rich region within the promoter regions of specific genes. KLF10 is downregulated in human cancers. However, the role of KLF10 in gastric cancer formation remains unclear. Materials and Methods: In this study, we performed immunohistochemical staining for KLF10 expression in 121 gastric cancer sections. Results: The loss of KLF10 expression was correlated with advanced stages and T status. Kaplan-Meier analysis revealed that patients with higher KLF10 levels had longer overall survival than those with lower KLF10 levels. Univariate analysis revealed that in patients with gastric cancer, advanced stages and low KLF10 levels were associated with survival. Multivariate analysis indicated that age, gender, advanced stages, and KLF10 expression were independent prognostic factors of the survival of patients with gastric cancer. After adjusting for age, gender, and stage, KLF10 expression was also found to be an independent prognostic factor in the survival of patients with gastric cancer. Conclusion: Our results collectively suggested that KLF10 may play a critical role in gastric cancer formation and is an independent prognosis factor of gastric cancer.

Keywords: KLF10; gastric cancer; prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The expression patterns of KLF10 in gastric cancer. (A) Representative Immunohistochemistry (IHC) images of immunohistochemical staining of KLF10 gastric tissues. Left panel: IHC staining of normal gastric tissue. Middle panel: positive IHC staining region in normal gastric tissues. Right: IHC staining without KLF10 antibody in gastric tissues as negative control. All images magnification ×100. Scale bar: 5 µM. (B) Immunohistochemical staining of KLF10 in gastric cancer. KLF10 was positively detected in the nuclear and cytoplasmic regions. Representative IHC intensity of images of negative (upper panel, left), 1+ (upper panel, right), 2+ (lower panel, left) and 3+ (lower panel, right) were shown. All images magnification ×400. Scale bar: 20 µM.
Figure 2
Figure 2
The prognostic significance of KLF10 in gastric cancer. Kaplan–Meier survival curve for the 121 gastric cancer patients with KLF10 protein expression. Patients with high KLF10 expression had a significantly better overall survival rate compared to patients with low KLF10 expression, as defined by a log-rank test (p = 0.033).
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