Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 3;58(6):760.
doi: 10.3390/medicina58060760.

HPV and HIV Coinfection in Women from a Southeast Region of Romania-PICOPIV Study

Simona Claudia Cambrea  1   2 , Mariana Aschie  1   3   4 , Ghiulendan Resul  2   3   4 , Anca Florentina Mitroi  3   5 , Anca Chisoi  3   5 , Antonela Anca Nicolau  3   5 , Gabriela Izabela Baltatescu  3   5 , Ana Maria Cretu  3   5 , Gabriela Lupasteanu  6 , Lucian Serbanescu  1   5 , Mihaela Manea  3 , Sebastian Theodor Topliceanu  3   4 , Lucian Cristian Petcu  7 , Loredana Pazara  1 , Georgeta Camelia Cozaru  3   5
Affiliations

HPV and HIV Coinfection in Women from a Southeast Region of Romania-PICOPIV Study

Simona Claudia Cambrea et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. The aim of study was to establish the prevalence of HPV infection among HIV-positive women in Southeast Region of Romania, to genotype high risk HPV types -and to correlate the results with clinical data and cytological cervical lesions. Materials and Methods: 40 HIV-positive women were screened for HPV types and for cytological cervical lesions. The findings were evaluated in correlation with CD4 cell counts, HIV viral load, age at first sexual intercourse, number of sexual partners, vaginal candidiasis, and Gardnerella using statistical methods. Results: 19/40 (47.5%) women were positive for HPV types, 63.15% infected with single HPV type and 36.85% with multiple HPV types. The most frequent types were type: 31 (42.1%), 56 (31.57%), 53 (15.78%). On cytology, 34 (85%) women were found with NILM of which 38.23% were HPV-positive. Fifteen percent of women had abnormal cytology (three ASC-US, three LSIL), and all of them were HPV-positive. Through analyzing the value of CD4 count, women with CD4 count ≤ 200 cells/μL were found to be significantly more likely to be infected with HPV; meanwhile there was no correlation between the detection of HPV types and HIV viral load. Candida or Gardnerella were more often associated with HIV-positive women with HPV, than in women without HPV. Conclusions: Infection with HPV types is common among HIV-positive women in the Southeast Region of Romania and it is associated with age at the beginning of sexual life, number of sexual partners, CD4 value, vaginal candidiasis, and Gardnerella infection.

Keywords: CD4; HIV; HPV; antiretroviral therapy; cervical precancerous lesions; coinfection; high risk; pap cytology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Frequencies of HR-HPV types.
Figure 2
Figure 2
HPV distribution regarding cytology findings.
Figure 3
Figure 3
Cytology findings in different HR-HPV types.
Figure 4
Figure 4
Correlation of HPV with CD4 counts.
Figure 5
Figure 5
Correlation of HPV with HIV viral load.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ho G.Y., Bierman R., Beardsley L., Chang C.J., Burk R.D. Natural history of cervicovaginal papillomavirus infection in young women. N. Engl. J. Med. 1998;338:423–428. doi: 10.1056/NEJM199802123380703. - DOI - PubMed
    1. Burd E.M. Human papillomavirus and cervical cancer. Clin. Microbiol. Rev. 2003;16:1–17. doi: 10.1128/CMR.16.1.1-17.2003. - DOI - PMC - PubMed
    1. Li N., Franceschi S., Howell-Jones R., Snijders P.J., Clifford G.M. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int. J. Cancer. 2011;128:927–935. doi: 10.1002/ijc.25396. - DOI - PubMed
    1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human Papillomaviruses. Lyon (FR): International Agency for Research on Cancer. 2007. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 90.) 1, Human Papillomavirus (HPV) Infection. [(accessed on 10 October 2021)]; Available online: https://www.ncbi.nlm.nih.gov/books/NBK321770/ - PubMed
    1. Hausen H.Z. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer Inst. 2000;92:690–698. doi: 10.1093/jnci/92.9.690. - DOI - PubMed

MeSH terms

Grants and funding