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. 2022 Jun 8;58(6):776.
doi: 10.3390/medicina58060776.

Kisspeptin Variations in Patients with Polycystic Ovary Syndrome-A Prospective Case Control Study

Mona Akad  1   2 , Răzvan Socolov  1   2 , Cristina Furnică  1 , Roxana Covali  1   2 , Catalina Daniela Stan  1   2 , Eduard Crauciuc  1   2 , Ioana Pavaleanu  1   2
Affiliations

Kisspeptin Variations in Patients with Polycystic Ovary Syndrome-A Prospective Case Control Study

Mona Akad et al. Medicina (Kaunas). .

Abstract

Background and objectives: Kisspeptin, also named metastin, showed important roles in initiating the secretion of gonadotropin-releasing hormone (GnRH) and is an essential factor in the development of polycystic ovaries syndrome (PCOS). Several research studies noticed associations between kisspeptin levels and patients with anovulatory cycles due to PCOS with an increased LH/FSH ratio. The aim of our study was to bring scientific evidence regarding the correlation between high kisspeptin and luteinizing hormone values in subfertile women due to PCOS. Materials and Methods: A prospective case-control study was conducted in "Elena Doamna" Hospital of Obstetrics and Gynecology between 4 January 2021 and 1 March 2022. All patients agreed to participate in our study, had ages between 18 and 45 years old, and had a body mass index between 18.5 and 30 kg/m2. The study group consisted of subfertile patients with PCOS and menstrual disturbances, including amenorrhea or oligomenorrhea. The control group consisted of healthy patients with ovulatory cycles and no other reproductive or endocrinology pathologies. During the follicular phase of their menstrual cycle, patients had blood samples taken with the dosage of kisspeptin, LH, FSH, estradiol, insulin, glycemic levels, testosterone, and prolactin. Pelvic ultrasounds and clinical examinations were performed as well. Results: Significant differences were observed in kisspeptin, LH, FSH, and estradiol levels between patients with PCOS and the control group. After the univariate analysis, PCOS was significantly associated with increased kisspeptin, increased LH, and decreased FSH. There was no significant association between PCOS, estradiol, prolactin, and insulin. Conclusions: kisspeptin serum values are higher in subfertile PCOS patients, supporting the hypothesis that an over-stimulation of the KISS1 system might cause the hyper-stimulation of the HPG-axis.

Keywords: infertility; kisspeptin; polycystic ovary syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Univariate analysis of the relationship between kisspeptin serum levels and PCOS (p < 0.001).
Figure 2
Figure 2
Univariate analysis of the relationship between FSH serum levels and PCOS (p < 0.005). Circles represent high potential outliers and the stars represent high extreme values.
Figure 3
Figure 3
Univariate analysis between body mass index and PCOS (p < 0.01). Circles represent high potential outliers and the stars represent high extreme values.
Figure 4
Figure 4
Univariate analysis between LH serum levels and PCOS (p < 0.001). Circles represent high potential outliers and the stars represent high extreme values.
See this image and copyright information in PMC

References

    1. Lee J.H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl. Cancer Inst. 1996;88:1731–1737. doi: 10.1093/jnci/88.23.1731. - DOI - PubMed
    1. Skorupskaite K., George J.T., Anderson R.A. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum. Reprod. Update. 2014;20:485–500. doi: 10.1093/humupd/dmu009. - DOI - PMC - PubMed
    1. Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;31:613–617. doi: 10.1038/35079135. - DOI - PubMed
    1. College W.H. Kisspeptins and GnRH neuronal signalling. Trends Endocrinol. Metab. 2009;20:115–121. doi: 10.1016/j.tem.2008.10.005. - DOI - PubMed
    1. Roseweir A.K., Kauffman A.S., Smith J.T., Guerriero K.A., Morgan K., Pielecka-Fortuna J., Pineda R., Gottsch M.L., Tena-Sempere M., Moenter S.M., et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J. Neurosci. 2009;29:3920–3929. doi: 10.1523/JNEUROSCI.5740-08.2009. - DOI - PMC - PubMed