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Review
. 2022 Jun 17;58(6):817.
doi: 10.3390/medicina58060817.

Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease

Melissa Rivas  1 , Gayatri Gupta  2 , Louis Costanzo  1 , Huma Ahmed  1 , Anne E Wyman  1 , Patrick Geraghty  1
Affiliations
Review

Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease

Melissa Rivas et al. Medicina (Kaunas). .

Abstract

Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated lung aging. Over the past two decades, mounting evidence suggests an accumulation of senescent cells within the lungs of patients with COPD that contributes to dysregulated tissue repair and the secretion of multiple inflammatory proteins, termed the senescence-associated secretory phenotype (SASP). Cellular senescence in COPD is linked to telomere dysfunction, DNA damage, and oxidative stress. This review gives an overview of the mechanistic contributions and pathologic consequences of cellular senescence in COPD and discusses potential therapeutic approaches targeting senescence-associated signaling in COPD.

Keywords: aging; chronic obstructive pulmonary disease; cigarette smoke; senescence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Possible mechanisms for senescence in COPD. Created with BioRender.com.
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