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Review
. 2022 May 27;14(6):1151.
doi: 10.3390/pharmaceutics14061151.

Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review

Annalisa Itro  1 , Maria Consiglia Trotta  2 , Roberta Miranda  3 , Marco Paoletta  3 , Annalisa De Cicco  3 , Caterina Claudia Lepre  2 , Umberto Tarantino  4 , Michele D'Amico  2 , Giuseppe Toro  3 , Alfredo Schiavone Panni  3
Affiliations
Review

Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review

Annalisa Itro et al. Pharmaceutics. .

Abstract

The aim of the present systematic review was to provide a clear overview of the clinical current research progress in the use of adipose-derived mesenchymal stem cells (ASCs) as an effective therapeutic option for the management of tendinopathies, pathologies clinically characterized by persistent mechanical pain and structural alteration of the tendons. The review was carried out using three databases (Scopus, ISI Web of Science and PubMed) and analyzed records from 2013 to 2021. Only English-language papers describing the isolation and manipulation of adipose tissue as source of ASCs and presenting ASCs as treatment for clinical tendinopathies were included. Overall, seven clinical studies met the inclusion criteria and met the minimum quality inclusion threshold. Data extraction and quality assessment were performed by groups of three reviewers. The available evidence showed the efficacy and safety of ASCs treatment for tendinopathies, although it lacked a clear description of the biomolecular mechanisms underlying the beneficial properties of ASCs.

Keywords: adipose-derived mesenchymal stem cells; humans; tendinopathies; tendons repair.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart diagram of the study selection process for this systematic review.
See this image and copyright information in PMC

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