Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 28;14(6):1180.
doi: 10.3390/v14061180.

Burden and Trends of Acute Viral Hepatitis in Asia from 1990 to 2019

Qiao Liu  1 , Min Liu  1 , Jue Liu  1   2
Affiliations

Burden and Trends of Acute Viral Hepatitis in Asia from 1990 to 2019

Qiao Liu et al. Viruses. .

Abstract

Asia has a very high burden of acute hepatitis; thus, a comprehensive study of the current burden and long-term trends of acute hepatitis in Asia is needed. We aimed to assess the current status and trends from 1990 to 2019 of acute hepatitis burden in Asia, using the data from the Global Burden of Diseases Study 2019 (GBD 2019) results. Methods: We used the data from the GBD 2019. Absolute death, incidence, and disability adjusted life years (DALY) number and rate of acute hepatitis in Asia were derived from the database from 1990 to 2019. Age-standardized mortality, incidence and DALY rates (ASMR, ASIR and ASDR) were used to compare populations in different regions and times. The estimated annual percentage change (EAPC) in the rates quantified the trends of the acute hepatitis burden. Results: From 1990 to 2019, the ASMR and ASDR of acute hepatitis decreased significantly at different paces, with the largest decrease in acute hepatitis C and the smallest in acute hepatitis E. The ASIR of acute hepatitis decreased relatively slowly, by an average of 0.06% (95% CI, 0.05-0.08%) per year in acute hepatitis A, 0.91% (0.64-1.18%) per year in acute hepatitis C and 0.26% (0.24-0.28%) per year in acute hepatitis E; while the ASIR of acute hepatitis B decreased by an average of 1.95% (1.08-2.11) per year. From 1990 to 2019, the incidence rate of acute hepatitis A increased in most age groups (from the age of 5 to 70), with the 50-55 years group having the fastest increase by an average of 1.81% (95% CI, 1.67-1.95%) per year. In 2019, Afghanistan had the highest ASMR (10.44 per 100,000) and ASDR (357.85 per 100,000) of acute hepatitis, and the highest ASIR was in Mongolia (4703.14 per 100,000). Conclusions: In Asia, the burden of acute viral hepatitis was at a relatively high level, compared with the other four continents. International cooperation and multifaceted and multisectoral actions are needed for Asian countries to eliminate viral hepatitis and to contribute to the global elimination of viral hepatitis.

Keywords: Asia; acute viral hepatitis; burden; trends.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Trends of age-standardized incidence rate and absolute incidence number of acute hepatitis in Asia, America, Africa, Europe and Oceania from 1990 to 2019.
Figure 2
Figure 2
(A) Sex diversities in acute hepatitis in Asia in 1990 and 2019; (B) trends of age-standardized rate of deaths, incidence and DALYs of acute hepatitis in Asia, from 1990 to 2019. DALY, disability adjusted life year.
Figure 3
Figure 3
Age-specific mortality, incidence and DALY rates of acute hepatitis in Asia in 1990 and 2019. DALY, disability adjusted life year.
Figure 4
Figure 4
EAPCs in different age groups of acute hepatitis in Asia and the corresponding 95% CIs, from 1990 to 2019. EAPC, estimated annual percentage change; CI, confident interval.
Figure 5
Figure 5
EAPCs and age-standardized rate of (A) DALYs, (B) deaths and (C) incidence of acute hepatitis burden in Asian countries. EAPC, estimated annual percentage change; DALY, disability adjusted life year.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. World Health Organization Fact-Sheet: Hepatitis. 2022. [(accessed on 10 April 2022)]. Available online: https://www.who.int/health-topics/hepatitis#tab=tab_1.
    1. Wendon J., Cordoba J., Dhawan A., Larsen F.S., Manns M., Samuel D., Simpson K.J., Yaron I. EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure. J. Hepatol. 2017;66:1047–1081. doi: 10.1016/j.jhep.2016.12.003. - DOI - PubMed
    1. Stravitz R.T., Lee W.M. Acute liver failure. Lancet. 2019;394:869–881. doi: 10.1016/S0140-6736(19)31894-X. - DOI - PMC - PubMed
    1. World Health Organization Global Hepatitis Report, 2017. 2017. [(accessed on 10 April 2022)]. Available online: https://www.who.int/publications-detail-redirect/9789241565455.
    1. James S.L., Abate D., Abate K.H., Abay S.M., Abbafati C., Abbasi N., Abbastabar N., Abd-Allah F., Abdela J., Abdelalim A., et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789–1858. doi: 10.1016/S0140-6736(18)32279-7. - DOI - PMC - PubMed

Publication types