Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;46(10):e14283.
doi: 10.1111/jfbc.14283. Epub 2022 Jun 23.

Microencapsulated bioactive peptides from brewer's spent grain promotes antihypertensive and antidiabetogenic effects on a hypertensive and insulin-resistant rat model

Antonela G Garzón  1 , María Del Rosario Ferreira  2 , Raul E Cian  1 , Maria Eugenia Oliva  2 , Maria Eugenia D'Alessandro  2 , Silvina R Drago  1
Affiliations

Microencapsulated bioactive peptides from brewer's spent grain promotes antihypertensive and antidiabetogenic effects on a hypertensive and insulin-resistant rat model

Antonela G Garzón et al. J Food Biochem. 2022 Oct.

Abstract

The effects of microcapsules containing brewer's spent grain (BSG) peptides were evaluated on a hypertensive/insulin-resistant rat model induced by a sucrose-rich diet (SRD) administration. Animals received for 100 days the control diet (CD), SRD, and CD and SRD diets supplemented with microencapsulated peptides (CD-P and SRD-P). During the experimental period, blood pressure was monitored. Glycemia, tissue glycogen content, nitric oxide, and the activity of enzymes related to hypertensive and diabetogenic mechanisms were determined. The consumption of SRD caused hypertensive and hyperglycemic effects compared to CD. However, the SRD-P group presented lower systolic pressure at the middle of ingestion, achieving similar values than the CD. The SRD-P rats decreased all enzymes' activities compared to the SRD reaching the values of CD, except for those of α-amylase in cecal content and DPP-IV in serum. It was possible to corroborate potential antihypertensive and antidiabetogenic in vivo effects of the microencapsulated BSG peptides. PRACTICAL APPLICATIONS: Brewer's spent grain (BSG) is the main waste obtained from brewing industry. Bioactive peptides obtained after an enzymatic hydrolysis of proteins with in vitro antihypertensive and antidiabetogenic activity have been described. However, to corroborate the action of these bioactive peptides, in vivo studies are necessary. In the present work, microcapsules containing bioactive peptides from BSG were administered on the rat model with induced hypertension and insulin-resistance, corroborating an in vivo antihypertensive and antidiabetogenic effects by inhibition of enzymes related with blood pressure regulation and glucose metabolism. This work demonstrated that microcapsules of BSG peptides could be included into functional foods formulations, or used as dietary supplement for improving health and the prevention of non-communicable diseases, adding value to the brewing process by-product.

Keywords: Brewer's spent grain; Wistar rats; antidiabetogenic; antihypertensive; bioactive peptides.

PubMed Disclaimer

References

REFERENCES

    1. A.O.A.C. (2002). Official methods of analysis. Association of Official Analytical Chemist.
    1. Aluko, R. E. (2015). Antihypertensive peptides from food proteins. Annual Review of Food Science and Technology, 6, 235-262.
    1. Cermeño, M., Connolly, A., O'Keeffe, M. B., Flynn, C., Alashi, A. M., Aluko, R. E., & FitzGerald, R. J. (2019). Identification of bioactive peptides from brewers' spent grain and contribution of leu/Ile to bioactive potency. Journal of Functional Foods, 60, 103455.
    1. Cian, R. E., Salgado, P. R., Mauri, A. N., & Drago, S. R. (2019). Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers' spent grain with ACE-I inhibitory activity. International Journal of Food Science and Technology, 55, 1311-1317.
    1. Connolly, A., O'Keeffe, M. B., Nongonierma, A. B., Piggott, C. O., & FitzGerald, R. J. (2017). Isolation of peptides from a novel brewers spent grain protein isolate with potential to modulate glycaemic response. International Journal of Food Science, 52, 146-153.

Publication types

LinkOut - more resources