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. 2022 Jun 17:17:1393-1401.
doi: 10.2147/COPD.S360793. eCollection 2022.

Triglyceride-Glucose Index is a Risk Marker of Incident COPD Events in Women

Suneela Zaigham  1 , Hanan Tanash  2 , Peter M Nilsson  1   3 , Iram F Muhammad  1
Affiliations

Triglyceride-Glucose Index is a Risk Marker of Incident COPD Events in Women

Suneela Zaigham et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Purpose: The triglyceride-glucose index (TyG index) is a marker of insulin resistance and metabolic dysfunction and has the advantage of being universally available. Although recent evidence suggests the TyG index has relevance to respiratory health, there have been no prospective studies assessing its value as a biomarker for chronic lung diseases. We aim to assess the TyG index as a potential risk marker for future incident COPD events in the general population.

Patients and methods: Baseline TyG index was assessed in 28,282 middle-aged men and women without previous history of chronic obstructive pulmonary disease (COPD) from the Malmö Preventive Project (men between 1974 and 1982 and women between 1982 and 1992). All subjects were followed up prospectively, and Cox proportional hazards regression was used to assess incident COPD events according to quartiles of TyG index.

Results: After an average of 31 years of follow-up, TyG index was a strong predictor of future COPD events even after adjusting for potential confounders (Q4 (highest TyG index) HR (95% CI): 1.21 (1.09-1.35) vs Q1 (reference), p-trend <0.001). After stratifying by sex, the results remained statistically significant in women only (Q4 vs Q1 HR 1.72 (1.41-2.09)). Additionally, the risk remained significant in a cohort of life-long never smokers (Q4 vs Q1 HR 1.47 (1.08-2.01)).

Conclusion: A raised TyG index is a novel risk marker of future incident COPD events in women. Insulin resistance as reflected by the TyG index can precede the development of obstructive lung disease and as such may be an easily measurable and useful predictor of COPD in women.

Keywords: chronic obstructive pulmonary disease; cohort study; epidemiology; risk prediction; triglyceride-glucose index.

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Conflict of interest statement

SZ, HT, PMN and IFM have no conflicts of interests in relation to this work to declare. The baseline screening of participants in the Malmö Preventive Project (MPP) study was supported by the City of Malmö, the Swedish Medical Research Council, and the Swedish Heart and Lung Foundation. All data accessed complied with the relevant data protection and privacy regulations.

Figures

Figure 1
Figure 1
Kaplan–Meier survival curves of incident COPD by quartiles of TyG index. Q1: lowest TyG index, Q4: Highest TyG index.
Figure 2
Figure 2
Kaplan–Meier event-free survival curves of incident COPD by quartiles of TyG index in women Q1: lowest TyG index, Q4: Highest TyG index.
Figure 3
Figure 3
Kaplan–Meier event-free survival curves of incident COPD by quartiles of TyG index in men Q1: lowest TyG index, Q4: Highest TyG index.
See this image and copyright information in PMC

References

    1. Cebron Lipovec N, Beijers RJH, van den Borst B, Doehner W, Lainscak M, Schols AM. The prevalence of metabolic syndrome in chronic obstructive pulmonary disease: a systematic review. COPD. 2016;13(3):399–406. doi: 10.3109/15412555.2016.1140732 - DOI - PubMed
    1. Jones PW, Nadeau G, Small M, Adamek L. Characteristics of a COPD population categorised using the GOLD framework by health status and exacerbations. Respir Med. 2014;108(1):129–135. doi: 10.1016/j.rmed.2013.08.015 - DOI - PubMed
    1. Park SK, Larson JL. The relationship between physical activity and metabolic syndrome in people with chronic obstructive pulmonary disease. J Cardiovasc Nurs. 2014;29(6):499–507. doi: 10.1097/JCN.0000000000000096 - DOI - PMC - PubMed
    1. Duncan BB, Schmidt MI, Pankow JS, et al. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2003;52(7):1799–1805. doi: 10.2337/diabetes.52.7.1799 - DOI - PubMed
    1. Muhammad IF, Borné Y, Hedblad B, Nilsson PM, Persson M, Engström G. Acute-phase proteins and incidence of diabetes: a population-based cohort study. Acta Diabetol. 2016;53(6):981–989. doi: 10.1007/s00592-016-0903-8 - DOI - PMC - PubMed