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Review
. 2022 Jun 17:15:3561-3572.
doi: 10.2147/JIR.S366620. eCollection 2022.

The Role of Podoplanin in the Immune System and Inflammation

Zhiyuan Zhang #  1 , Nan Zhang #  1 , Jing Yu #  1 , Wenting Xu  1 , Jiameng Gao  1 , Xin Lv  1 , Zongmei Wen  1
Affiliations
Review

The Role of Podoplanin in the Immune System and Inflammation

Zhiyuan Zhang et al. J Inflamm Res. .

Abstract

Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.

Keywords: immune system; inflammation; podoplanin.

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Conflict of interest statement

The authors have declared no conflicts of interest in relation to this work.

Figures

Figure 1
Figure 1
The involvement of podoplanin in the immune system and inflammatory diseases.
See this image and copyright information in PMC

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