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Case Reports
. 2022 Jun 14:2022:9694911.
doi: 10.1155/2022/9694911. eCollection 2022.

Massive Intestinal Bleeding in an Adult with IgA Vasculitis Treated with Intravenous Immunoglobulin

Ibrahim Nassereddin  1 , Ariel Kenig  1 , Yuval Ishay  1   2 , Hillel Lehmann  1 , Noa Hurvitz  1 , Narmine Elkhateeb  1 , Ram Gelman  1 , Yael Ratz  1 , Inon Sarig  1 , Ido Burstain  1   3 , Stephanie Benshushan  4 , Fadi Kharouf  1   5
Affiliations
Case Reports

Massive Intestinal Bleeding in an Adult with IgA Vasculitis Treated with Intravenous Immunoglobulin

Ibrahim Nassereddin et al. Case Rep Rheumatol. .

Abstract

We report the case of a 29-year-old adult presenting with severe IgA vasculitis, with cutaneous, urologic, and renal manifestations. The late appearance of severe gastrointestinal bleeding dominated the clinical picture, necessitating the administration of tens of units of packed cells and the augmentation of the immunosuppressive protocol. It was not until therapy with intravenous immunoglobulin (IVIG) was introduced that the massive bleeding was controlled. We herein discuss the patient's presentation, the gastrointestinal manifestations of IgA vasculitis, the recommended treatments, and the existent evidence about IVIG therapy.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Renal biopsy with glomerular mesangial expansion and mesangial hypercellularity, including segmental neutrophil influx (arrows and arrowheads) (H&E, original magnification, ×200). H&E: hematoxylin and eosin.
Figure 2
Figure 2
Early cellular crescents (arrows) are seen (PAS stain, original magnification, ×160). PAS: Periodic acid–Schiff.
See this image and copyright information in PMC

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