Reversible Cytotoxic Lesion of the Corpus Callosum and COVID-19

doi:10.1177/19418744211039374

. 2022 Jul;12(3):585-586.

doi: 10.1177/19418744211039374. Epub 2022 May 17.

Reversible Cytotoxic Lesion of the Corpus Callosum and COVID-19

Jesús Garcia Castro¹, Cristina Utrilla Contreras², Ángel Martín Montes¹

Affiliations

¹ Department of Neurology, La Paz University Hospital, Madrid, Spain.
² Department of Radiology, La Paz University Hospital, Madrid, Spain.

PMID: 35747765
PMCID: PMC9117954
DOI: 10.1177/19418744211039374

Reversible Cytotoxic Lesion of the Corpus Callosum and COVID-19

Jesús Garcia Castro et al. Neurohospitalist. 2022 Jul.

. 2022 Jul;12(3):585-586.

doi: 10.1177/19418744211039374. Epub 2022 May 17.

Authors

Jesús Garcia Castro¹, Cristina Utrilla Contreras², Ángel Martín Montes¹

Affiliations

¹ Department of Neurology, La Paz University Hospital, Madrid, Spain.
² Department of Radiology, La Paz University Hospital, Madrid, Spain.

PMID: 35747765
PMCID: PMC9117954
DOI: 10.1177/19418744211039374

No abstract available

Keywords: COVID-19; corpus callosum; magnetic resonance imaging.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

**Figure 1.**
Axial magnetic resonance (MR) images demonstrate an oval fluid attenuated inversion recovery (FLAIR) hyperintensity in the splenium of the corpus callosum (A) with associated restricted diffusion on the diffusion weighted imaging (DWI) (B) and apparent diffusion coefficient (ADC) maps (C), compatible with cytotoxic edema.

**Figure 2.**
Follow-up MR imaging performed 3 months later showed almost complete resolution of the abnormal signal on axial FLAIR (A), DWI (B) and ADC map (C).

See this image and copyright information in PMC

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References

1. Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain Behav. 2019;9(11):e01440. doi:10.1002/brb3.1440 - DOI - PMC - PubMed
1. Moreau A, Ego A, Vandergheynst F, et al. Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection. J Neurol. 2021;268(5):1592-1594. doi:10.1007/s00415-020-10164-3 - DOI - PMC - PubMed
1. Edjlali M, le Gal A, Louvet M, et al. Teaching NeuroImages: cytotoxic lesions of the corpus callosum in encephalopathic patients with COVID-19. Neurology. 2020;95(22):1021-1022. doi:10.1212/WNL.0000000000010880 - DOI - PubMed
1. Gaur P, Dixon L, Jones B, Lyall H, Jan W. COVID-19-associated cytotoxic lesions of the corpus callosum. Am J Neuroradiol. 2020;41(10):1905-1907. doi:10.3174/ajnr.A6713 - DOI - PMC - PubMed
1. Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: Mechanisms, causes, and manifestations. Radiographics. 2017;37(2):562-576. doi:10.1148/rg.2017160085 - DOI - PubMed

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[1] Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain Behav. 2019;9(11):e01440. doi:10.1002/brb3.1440 - DOI - PMC - PubMed

[2] Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain Behav. 2019;9(11):e01440. doi:10.1002/brb3.1440 - DOI - PMC - PubMed

[3] Moreau A, Ego A, Vandergheynst F, et al. Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection. J Neurol. 2021;268(5):1592-1594. doi:10.1007/s00415-020-10164-3 - DOI - PMC - PubMed

[4] Moreau A, Ego A, Vandergheynst F, et al. Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection. J Neurol. 2021;268(5):1592-1594. doi:10.1007/s00415-020-10164-3 - DOI - PMC - PubMed

[5] Edjlali M, le Gal A, Louvet M, et al. Teaching NeuroImages: cytotoxic lesions of the corpus callosum in encephalopathic patients with COVID-19. Neurology. 2020;95(22):1021-1022. doi:10.1212/WNL.0000000000010880 - DOI - PubMed

[6] Edjlali M, le Gal A, Louvet M, et al. Teaching NeuroImages: cytotoxic lesions of the corpus callosum in encephalopathic patients with COVID-19. Neurology. 2020;95(22):1021-1022. doi:10.1212/WNL.0000000000010880 - DOI - PubMed

[7] Gaur P, Dixon L, Jones B, Lyall H, Jan W. COVID-19-associated cytotoxic lesions of the corpus callosum. Am J Neuroradiol. 2020;41(10):1905-1907. doi:10.3174/ajnr.A6713 - DOI - PMC - PubMed

[8] Gaur P, Dixon L, Jones B, Lyall H, Jan W. COVID-19-associated cytotoxic lesions of the corpus callosum. Am J Neuroradiol. 2020;41(10):1905-1907. doi:10.3174/ajnr.A6713 - DOI - PMC - PubMed

[9] Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: Mechanisms, causes, and manifestations. Radiographics. 2017;37(2):562-576. doi:10.1148/rg.2017160085 - DOI - PubMed

[10] Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: Mechanisms, causes, and manifestations. Radiographics. 2017;37(2):562-576. doi:10.1148/rg.2017160085 - DOI - PubMed

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Reversible Cytotoxic Lesion of the Corpus Callosum and COVID-19

Affiliations

Reversible Cytotoxic Lesion of the Corpus Callosum and COVID-19

Authors

Affiliations

Conflict of interest statement

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