Letter: gut-brain axis dysfunction underlies symptom generation in irritable bowel syndrome-a plea for rational interpretation of irrational doses of FODMAPs. Authors' reply

Jessica R Biesiekierski¹, Jie Wu², Lukas Van Oudenhove^{3

4

5}

Affiliations

¹ Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.
² Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, China.
³ Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Centre for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
⁴ Leuven Brain Institute, KU Leuven, Leuven, Belgium.
⁵ Cognitive & Affective Neuroscience Lab, Department of Psychological & Brain Sciences, Dartmouth College, Hanover, New Hampshire, USA.

Comment

Jessica R Biesiekierski et al. Aliment Pharmacol Ther. 2022 Jul.

. 2022 Jul;56(2):368-369.

doi: 10.1111/apt.17074.

Jessica R Biesiekierski¹, Jie Wu², Lukas Van Oudenhove^{3

4

5}

¹ Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.
² Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, China.
³ Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Centre for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
⁴ Leuven Brain Institute, KU Leuven, Leuven, Belgium.
⁵ Cognitive & Affective Neuroscience Lab, Department of Psychological & Brain Sciences, Dartmouth College, Hanover, New Hampshire, USA.

No abstract available

Comment on

Gut-brain axis dysfunction underlies FODMAP-induced symptom generation in irritable bowel syndrome.
Wu J, Masuy I, Biesiekierski JR, Fitzke HE, Parikh C, Schofield L, Shaikh H, Bhagwanani A, Aziz Q, Taylor SA, Tack J, Van Oudenhove L. Wu J, et al. Aliment Pharmacol Ther. 2022 Mar;55(6):670-682. doi: 10.1111/apt.16812. Epub 2022 Feb 15. Aliment Pharmacol Ther. 2022. PMID: 35166384 Clinical Trial.
Letter: gut-brain axis dysfunction underlies symptom generation in irritable bowel syndrome-a plea for rational interpretation of irrational doses of FODMAPs.
Halmos EP, Gibson PR. Halmos EP, et al. Aliment Pharmacol Ther. 2022 Jul;56(2):366-367. doi: 10.1111/apt.16975. Aliment Pharmacol Ther. 2022. PMID: 35748832 No abstract available.

1. Wu J, Masuy I, Biesiekierski JR, Fitzke HE, Parikh C, Schofield L, et al. Gut-brain axis dysfunction underlies FODMAP-induced symptom generation in irritable bowel syndrome. Aliment Pharmacol Ther. 2022;55:670-682.
1. Halmos EP, Gibson PR. Letter: gut-brain axis dysfunction underlies symptom generation in irritable bowel syndrome - a plea for rational interpretation of irrational doses of FODMAPs. Aliment Pharmacol Ther. 2022;56:365-366.
1. Masuy I, Van Oudenhove L, Tack J, Biesiekierski J. Effect of intragastric FODMAP infusion on upper gastrointestinal motility, gastrointestinal, and psychological symptoms in irritable bowel syndrome vs healthy controls. Neurogastroenterol Motil. 2018;30(1):e13167.
1. Major G, Pritchard S, Murray K, Alappadan JP, Hoad CL, Marciani L, et al. Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome. Gastroenterology. 2017;152(1):124-33.
1. Tillisch K, Mayer EA, Labus JS. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology. 2011;140(1):91-100.