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Comment
. 2022 Jun 23;185(13):2201-2203.
doi: 10.1016/j.cell.2022.05.028.

APOE told me put my fat in the bag and nobody gets hurt

Garam Kim  1 , Aaron D Gitler  2
Affiliations
Free article
Comment

APOE told me put my fat in the bag and nobody gets hurt

Garam Kim et al. Cell. .
Free article

Abstract

The ε4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer's disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report APOE-driven cell-type-specific changes that may contribute to Alzheimer's disease risk.

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Conflict of interest statement

Declaration of interests A.D.G. is a founder of Maze Therapeutics and is on the scientific advisory board of Alector.

Comment on

  • Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
    Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Tcw J, et al. Cell. 2022 Jun 23;185(13):2213-2233.e25. doi: 10.1016/j.cell.2022.05.017. Cell. 2022. PMID: 35750033 Free PMC article.

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