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. 2022 Jun 23;185(13):2208-2209.
doi: 10.1016/j.cell.2022.05.025.

TIR domains as two-tiered enzymes to activate plant immunity

Lei Tian  1 , Xin Li  2
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TIR domains as two-tiered enzymes to activate plant immunity

Lei Tian et al. Cell. .
Free article

Abstract

Plant immune receptors often contain TIR domains, which can oligomerize to form active enzyme complexes in response to pathogen infections. In this issue of Cell, Yu and colleagues discover that some plant TIR domains possess a novel 2',3'-cAMP/cGMP synthetase activity that cleaves double-stranded RNA/DNA, triggering cell death during plant immune responses.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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