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. 2022 Jul 11;40(7):703-705.
doi: 10.1016/j.ccell.2022.06.003. Epub 2022 Jun 23.

Training the host organism to enhance anti-cancer immunity

Miriam Ferrer  1 , Tobias Janowitz  2
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Training the host organism to enhance anti-cancer immunity

Miriam Ferrer et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Kurz et al. demonstrate in an orthotopic pancreatic cancer model that low-intensity exercise improves tumor control and response to immunotherapy in an IL-15-dependent manner. Combination therapy, IL-15 super-agonist, anti-PD-1 antibody and chemotherapy, strongly reduces tumor growth. Therefore, the study opens rich translational avenues.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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