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. 2023 Mar 1;15(2):161-170.
doi: 10.1093/inthealth/ihac029.

Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study

Manthar Ali Mallah  1 , Til Bahadur Basnet  2 , Mukhtiar Ali  3 , Fuwei Xie  4 , Xiang Li  4 , Feifei Feng  1 , Wei Wang  1 , Pingping Shang  4 , Qiao Zhang  1
Affiliations

Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study

Manthar Ali Mallah et al. Int Health. .

Abstract

Background: The primary aim of this study is to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus (DM) among the US population.

Methods: We used data from the National Health and Nutritional Examination Survey 2003-16, which is a nationally representative population-based survey of the US non-institutionalized population. Logistic regression analysis was performed to evaluate the association between urinary PAHs and the prevalence of DM using odds ratios (ORs) and 95% confidence intervals (CIs).

Results: The study sample including 13 792 individuals ≥18 y of age. The average ages of the three PAH tertiles were 42.56±19.67, 42.21±19.51 and 43.39±17.99 y. An increased risk of DM was found with increased odds for the second (OR 1.56 [95% CI 1.36 to 1.79]) and third tertile (OR 1.79 [95% CI 1.55 to 2.06)] of urinary PAH as compared with the first tertile. Similarly, higher chances of DM were observed in the second (men: OR 1.42 [95% CI 1.18 to 1.71]; women: OR 1.76 [95% CI 1.44 to 2.14]) and third tertile (men: OR 1.69 [95% CI 1.38 to 2.08]; women: OR 1.79 [95% CI 1.46 to 2.19]) of urinary PAHs as compared with the first tertile in both men and women.

Conclusions: A population-based cross-sectional study found a positive association between urinary PAHs and DM in the US population.

Keywords: diabetes mellitus; environmental contaminate; polycyclic aromatic hydrocarbon; urinary PAH.

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Figure 1.
Figure 1.
Eligible participants and those included in the analyses of the association between urinary PAHs and DM among the US population.
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