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Editorial
. 2022 Sep 22;44(4):363-365.
doi: 10.47626/1516-4446-2021-0041.

Promoting safer clozapine dosing in the Americas

Affiliations
Editorial

Promoting safer clozapine dosing in the Americas

Jose de Leon et al. Braz J Psychiatry. .
No abstract available

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Conflict of interest statement

GS has served as a consultant for HLS Therapeutics. The other authors report no conflicts of interest.

References

    1. de Leon J, Schoretsanitis G, Smith RL, Molden E, Solismaa A, Seppälä N, et al. An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels. Pharmacopsychiatry. 2021 Dec 15 doi: 10.1055/a-1625-6388. . Online ahead of print. - DOI - PubMed
    1. Nielsen R, Akey JM, Jakobsson M, Pritchard JK, Tishkoff S, Willerslev E. Tracing the peopling of the world through genomics. Nature. 2017;541:302–10. - PMC - PubMed
    1. de Leon J, Ruan CJ, Schoretsanitis G, De Las Cuevas C. A rational use of clozapine based on adverse drug reactions, pharmacokinetics, and clinical pharmacopsychology. Psychother Psychosom. 2020;89:200–14. - PMC - PubMed
    1. Ruan CJ, de Leon J. Is there a future for CYP1A2 pharmacogenetics in the optimal dosing of clozapine? Pharmacogenomics. 2020;21:369–73. - PubMed
    1. Ruan CJ, Zang YN, Cheng YH, Wang CY, de Leon J. Around 3% of 1,300 levels were elevated during infections in a retrospective review of 131 Beijing Hospital in-patients with more than 24,000 days of clozapine treatment. Psychother Psychosom. 2020;89:255–7. - PubMed

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