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Review
. 2022 Oct;167(2):139-153.
doi: 10.1111/imm.13529. Epub 2022 Jul 12.

Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model

Ramón A Juste  1   2 , Elisa Ferreras-Colino  3 , José de la Fuente  3   4 , Mercedes Domínguez  5 , María A Risalde  6   7 , Lucas Domínguez  8   9 , Alejandro Cabezas-Cruz  10 , Christian Gortázar  3
Affiliations
Free article
Review

Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model

Ramón A Juste et al. Immunology. 2022 Oct.
Free article

Abstract

Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that enhances their primary defensive capabilities. Cross-pathogen protective TRAIM can be triggered in different hosts by exposure to live microbes or microbe-derived products such as heat-inactivated Mycobacterium bovis or with the glycan α-Gal to elicit protective responses against several pathogens. We review the TRAIM paradigm using two models representing distinct scales of immune sensitization: the whole bacterial cell and one of its building blocks, the polysaccharides or glycans. Observations point out to macrophage lytic capabilities and cytokine regulation as two key components in non-specific innate immune responses against infections. The study of the TRAIM response deserves attention to better characterize the evolution of host-pathogen cooperation both for identifying the aetiology of some diseases and for finding new therapeutic strategies. In this field, the zebrafish provides a convenient and complete biological system that could help to deepen in the knowledge of TRAIM-mediated mechanisms in pathogen-host interactions.

Keywords: cross-protection; glycan alpha-Gal; heat-inactivated Mycobacterium bovis; macrophages; trained innate immunity.

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References

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