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. 2022 Oct;43(10):801-803.
doi: 10.1016/j.tips.2022.06.004. Epub 2022 Jun 23.

The calcium channel terminator: hasta la vista pain

Erika K Harding  1 , Gerald W Zamponi  2
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The calcium channel terminator: hasta la vista pain

Erika K Harding et al. Trends Pharmacol Sci. 2022 Oct.

Abstract

Chronic pain remains a major burden and is difficult to treat. N-type calcium channels may be a suitable therapeutic target for analgesics, and a new study from Colecraft and colleagues utilizes a clever new way to modulate their expression to achieve therapeutic benefits in preclinical models of neuropathic pain.

Keywords: beta subunit; calcium channel; pain; ubiquitination.

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