Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
- PMID: 35753987
- PMCID: PMC9189103
- DOI: 10.1016/j.jcf.2022.06.006
Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
Abstract
Background: This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen.
Results: SARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were solid-organ transplant recipients. 74.5% were symptomatic and 22% were admitted to hospital. In the non-transplanted cohort, 39.5% of patients with ppFEV1<40% were hospitalised with oxygen verses 3.2% with ppFEV >70%: a 17-fold increase in odds. Worse outcomes were independently associated with older age, non-white race, underweight body mass index, and CF-related diabetes. Prescription of highly effective CFTR modulator therapies was associated with a significantly reduced odds of being hospitalised with oxygen (AOR 0.43 95%CI 0.31-0.60 p<0.001). Transplanted patients were hospitalised with supplemental oxygen therapy (21.9%) more often than non-transplanted (8.8%) and was independently associated with the primary outcome (Adjusted OR 2.45 95%CI 1.27-4.71 p=0.007).
Conclusions: This is the first study to show that there is a protective effect from the use of CFTR modulator therapy and that people with CF from an ethnic minority are at more risk of severe infection with SARS-CoV-2.
Keywords: COVID-19; Coronavirus; Cystic fibrosis; SARS-CoV-2; Transplant.
Copyright © 2022. Published by Elsevier B.V.
Conflict of interest statement
COI Statement All authors declare no conflicts of interest in relationship to this work. Outside of this work the following authors declare payments or honoraria to them or their institution for a combination of lectures, presentations, educational events, advisory boards, steering groups, grants or consultancy fees: SC-Vertex, Chiesi, Profile, Zambon. RC- Vertex, P-RB – Astra-Zeneca, Boehringer Ingelheim, GSK, Insmed, Chiesi, Pfizer, Vertex, Zambon. I deM – Vertex,LN – Vertex, Boehringer,LVS-F – Vertex, AS -Vertex.
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Comment in
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The use of dornase alfa in patients with COVID-19.J Cyst Fibros. 2023 May;22(3):580. doi: 10.1016/j.jcf.2023.03.010. Epub 2023 Mar 13. J Cyst Fibros. 2023. PMID: 36966036 Free PMC article. No abstract available.
References
-
- Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N. K RFT future of cystic fibrosis care: a global perspective. LRMed. 2020 J 124. doi: 10. 1016/S2213 2600 (19)30337 6. E 2019 S 27. E in: LRMed 2019 DP 31570318. The future of cystic fibrosis care: a global perspective. Lancet Respiratory Medicine. 2020;8 (1):65–124. - PMC - PubMed
-
- Charman Susan, Lee Andrew, Cosgriff Rebecca, McClenaghan Elliot CS. Annual Report - UK CF Registry [Internet]. UK CF Registry Annual Report. 2019. Available from: https://www.cysticfibrosis.org.uk/the-work-we-do/uk-cf-registry/reportin...
-
- National Institutes of Health. No Title [Internet]. COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. Available from: https://www.covid19treatmentguidelines.nih.gov/. - PubMed
-
- Archangelidi O, Carr SB, Simmonds NJ, Bilton D, Banya W, Cullinan P. Non-invasive ventilation and clinical outcomes in cystic fibrosis: Findings from the UK CF registry. J Cystic Fibrosis. 2018 - PubMed
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