Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov;21(11):6174-6183.
doi: 10.1111/jocd.15187. Epub 2022 Jul 19.

The first broad replication study of SNPs and a pilot genome-wide association study for androgenetic alopecia in Asian populations

In-Young Kim  1 , Ji-Hye Kim  1 , Ja-Eun Choi  1 , So-Jin Yu  1 , Joo Hee Kim  2   3 , Soon Rye Kim  2   3 , Mi Soo Choi  2 , Myung Hwa Kim  2 , Kyung-Won Hong  1 , Byung-Cheol Park  2   3
Affiliations

The first broad replication study of SNPs and a pilot genome-wide association study for androgenetic alopecia in Asian populations

In-Young Kim et al. J Cosmet Dermatol. 2022 Nov.

Abstract

Background: Many candidate genes for androgenetic alopecia (AGA) have been identified in studies of the Caucasians and some Asian populations.

Aims: This study aimed to confirm the known susceptibility genes reported in previous studies and find additional candidate genes for high-risk individuals for AGA in Korean population.

Patients/methods: We recapitulated the previously reported SNPs and identified the novel Korean AGA risk genetic variants using a Korean hospital-based AGA case and control samples. The population was consisting of 494 individuals (275 AGA cases and 146 controls). Using the 800 K SNPs of precision medical research array (PMRA SNP microarray chip) and imputation-based SNPs, 12 previous GWAS reports for AGA and a total of 62 160 SNPs were examined in our study samples. Also, we conducted the genome-wide association study (GWAS) by the logistic regression analyses for AGA cases and controls with controlling the age as the covariates.

Results: Among the 62 160 SNPs, a total of 1143 SNPs in 76 gene regions showed weak replication tendency with the p-values <0.05 and same direction of effects. Additionally, the GWAS results showed 110 SNPs in 13 independent regions with the suggestive p-values <1.00 × 10-5 . The most significantly replicated SNP resided on chromosome 20, which were similar to other AGA replication studies including Chinese study. The GWAS identified two SNPs (rs11010734 and rs2420640) increasing the risk for AGA in our study population.

Conclusions: Our study would be a reference of the non-European studies to better understand AGA in different populations and ancestral contexts.

Keywords: androgenetic alopecia; gene expression; genetic.

PubMed Disclaimer

References

REFERENCES

    1. Nyholt DR, Gillespie NA, Heath AC, Martin NG. Genetic basis of male pattern baldness. J Invest Dermatol. 2003;121(6):1561-1564.
    1. Liu F, Hamer MA, Heilmann S, et al. Prediction of male-pattern baldness from genotypes. Eur J Hum Genet. 2016;24(6):895-902.
    1. Lee W-S, Lee H-J. Characteristics of androgenetic alopecia in Asian. Ann Dermatol. 2012;24(3):243-252.
    1. Yap CX, Sidorenko J, Wu Y, et al. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nat Commun. 2018;9(1):5407.
    1. Brockschmidt F, Heilmann S, Ellis JA, et al. Susceptibility variants on chromosome 7p21. 1 suggest HDAC9 as a new candidate gene for male-pattern baldness. Br J Dermatol. 2011;165(6):1293-1302.

LinkOut - more resources