Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 15:2022:1821719.
doi: 10.1155/2022/1821719. eCollection 2022.

Efficacy of Modified Qingre Jiedu Decoction Combined with Three-Dimensional Conformal Radiotherapy in Treating Moderate to Advanced Ovarian Carcinoma and Its Effect on Levels of Serum Carcinoembryonic Antigen and Carbohydrate Antigen 125

Shufen Ai  1 , Jin Xie  2
Affiliations

Efficacy of Modified Qingre Jiedu Decoction Combined with Three-Dimensional Conformal Radiotherapy in Treating Moderate to Advanced Ovarian Carcinoma and Its Effect on Levels of Serum Carcinoembryonic Antigen and Carbohydrate Antigen 125

Shufen Ai et al. Evid Based Complement Alternat Med. .

Abstract

Objective: To explore the efficacy of modified Qingre Jiedu decoction combined with three-dimensional conformal radiotherapy (3D-CRT) in treating moderate to advanced ovarian carcinoma (OC) and its effect on patients' serum carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125).

Methods: The clinical data of 84 patients with moderate to advanced OC treated in the gynecology department of Changqing District People's Hospital of Jinan from February 2017 to February 2018 were selected for retrospective analysis, and the patients were divided into the single chemotherapy group (taxol + carboplatin, n = 42) and the combined group (modified Qingre Jiedu decoction+3D-CRT, n = 42) according to the parity of their admission numbers. By measuring their levels of serum CEA and CA125 after treatment, the cellular immune levels of the two groups were compared.

Results: Compared with the single chemotherapy group after treatment, the combined group obtained significantly higher total clinical effective rate and 1-year, 2-year, and 3-year survival rates (P < 0.05), significantly higher CD4+/CD8+ and NK cell level values (P < 0.001), significantly lower serum CA125 and CEA level values (P < 0.001), and significantly lower total incidence rates of toxic and side effects (P < 0.05).

Conclusion: The abovementioned results show that the combined treatment modality has a significant effect on prolonging the survival of patients with moderate to advanced OC and can effectively reduce the levels of tumor markers and improve the body's immunity. Further study will be conducive to establishing a better solution for OC patients.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Study technical process.
Figure 2
Figure 2
Comparison of cellular immune levels after treatment between the two groups (mean ± SD, n = 42). (a) Comparison of the CD4+/CD8+ level values after treatment between the two groups. The horizontal axis indicates the combined group and the single chemotherapy group, and the vertical axis indicates the values. The mean CD4+/CD8+ level values of the combined group and the single chemotherapy group after treatment were 1.55 ± 0.19 and 1.30 ± 0.16, respectively. ∗ indicates a significant difference in the mean CD4+/CD8+ level values after treatment between the two groups (t = 6.523, P < 0.001). (b) The comparison of the NK cell level values after treatment between the two groups. The horizontal axis indicates the combined group and the single chemotherapy group, and the vertical axis indicates the values in %. The mean NK cell level values of the combined group and the single chemotherapy group after treatment were 25.56 ± 1.72% and 19.13 ± 1.27%, respectively. ∗∗ indicates a significant difference in the mean NK cell level values after treatment between the two groups (t = 19.490, P < 0.001).
Figure 3
Figure 3
Comparison of level values of serum tumor markers between the two groups (mean ± SD, n = 42). (a) The comparison of the CA125 level values after treatment between the two groups. The horizontal axis indicates the combined group and the single chemotherapy group, and the vertical axis indicates the values in U/ml. After treatment, the CA125 level values of the combined group and the single radiotherapy group were 37.39 ± 3.07 and 45.34 ± 3.07, respectively. ∗ indicates a significant difference in CA125 level values after treatment between the two groups (t = 11.867, P < 0.001). (b) The comparison of the CEA level values after treatment between the two groups. The horizontal axis indicates the combined group and the single chemotherapy group, and the vertical axis indicates the values in μg/L. After treatment, the CEA level values of the combined group and the single radiotherapy group were 6.31 ± 0.58 and 11.74 ± 1.24, respectively. ∗∗ indicates a significant difference in CEA level values after treatment between the two groups (t = 25.706, P < 0.001).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Corr B. R., Moroney M., Eckhardt S. G., Sawyer B., Behbakht K., Diamond J. R. Survival and clinical outcomes of patients with ovarian cancer who were treated on phase 1 clinical trials. Cancer . 2020;126(19):4289–4293. doi: 10.1002/cncr.33073. - DOI - PMC - PubMed
    1. Chen Y., Du H., Bao L., Liu W. Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review. Journal of Cancer . 2018;9(1):141–147. doi: 10.7150/jca.21187. - DOI - PMC - PubMed
    1. Nilsu Ç., Cenk U., Okan Ö. Dosimetric comparison of anterior posterior-posterior anterior 2-field three-dimensional conformal radiotherapy, 4-field three-dimensional conformal radiotherapy and “forward” plan intensity modulated radiotherapy techniques in female lymphoma patients irradiated to neck and mediastinum. Journal of Cancer Research and Therapeutics . 2018;14:1389–1396. - PubMed
    1. Ghosh G., Gupta G., Saroj D. Comparison three-dimensional conformal radiotherapy versus intensity modulated radiation therapy in local control of head and neck cancer. Journal of Cancer Research and Therapeutics . 2018;14:1412–1417. doi: 10.4103/jcrt.JCRT_725_17. - DOI - PubMed
    1. Mohanty S. K., Chopra S., Kannan S., et al. A comparative analysis of quality of life after postoperative intensity-modulated radiotherapy or three-dimensional conformal radiotherapy for cervical cancer. Indian Journal of Cancer . 2018;55:327–335. doi: 10.4103/ijc.IJC_453_17. - DOI - PubMed