Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Jun 8:13:910567.
doi: 10.3389/fphys.2022.910567. eCollection 2022.

Editorial: Lactate as a Major Signaling Molecule for Homeostasis

Luc Pellerin  1 , Philippe Connes  2 , Catherine Bisbal  3 , Karen Lambert  3
Affiliations
Editorial

Editorial: Lactate as a Major Signaling Molecule for Homeostasis

Luc Pellerin et al. Front Physiol. .
No abstract available

Keywords: GPR81/HCAR1; MCT; brain; lactate; metabolism; muscle.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
ATP, adenosine triphosphate; BDNF, brain-derived neutrophic factor; cAmp, cyclic adenosine monophosphate; HCAR1, hydroxycarboxylic acid receptor 1 or GPR81, G protein-coupled receptor 81; MCT, monocarboxylate transporter; P-PKA/PKA, ratio of phosphorylated cAMP-protein kinase A on total protein kinase A; SIRT1, sirtuin 1; UCP1, uncoupling protein 1.
See this image and copyright information in PMC

Comment on

  • Editorial on the Research Topic Lactate as a Major Signaling Molecule for Homeostasis

References

    1. Brooks G. A. (2020). Lactate as a Fulcrum of Metabolism. Redox Biol. 35, 101454. 10.1016/j.redox.2020.101454 - DOI - PMC - PubMed
    1. Dubouchaud H., Butterfield G. E., Wolfel E. E., Bergman B. C., Brooks G. A. (2000). Endurance Training, Expression, and Physiology of LDH, MCT1, and MCT4 in Human Skeletal Muscle. Am. J. Physiology-Endocrinology Metabolism 278 (4), E571–E579. 10.1152/ajpendo.2000.278.4.e571 - DOI - PubMed
    1. Lambert K., Py G., Eydoux N., Matecki S., Ramonatxo M., Préfaut C., et al. (2003). Effect of Food Restriction on Lactate Sarcolemmal Transport. Metabolism 52 (3), 322–327. 10.1053/meta.2003.50050 - DOI - PubMed
    1. Pellerin L. (2010). Food for Thought: the Importance of Glucose and Other Energy Substrates for Sustaining Brain Function under Varying Levels of Activity. Diabetes and Metabolism 36 (Suppl. 3), S59–S63. 10.1016/s1262-3636(10)70469-9 - DOI - PubMed
    1. Pérez-Escuredo J., Van Hée V. F., Sboarina M., Falces J., Payen V. L., Pellerin L., et al. (2016). Monocarboxylate Transporters in the Brain and in Cancer. Biochim. Biophys. Acta 1863 (10), 2481–2497. 10.1016/j.bbamcr.2016.03.013 - DOI - PMC - PubMed

Publication types

LinkOut - more resources