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. 2022 Jun 15:2022:9409749.
doi: 10.1155/2022/9409749. eCollection 2022.

Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images

Dan Zhu  1 , Qiang Sun  1 , Hong Yang  1 , Yangcheng Zou  1 , Chunmei Liu  1 , Yan Xu  1
Affiliations

Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images

Dan Zhu et al. Comput Math Methods Med. .

Abstract

The aim of this study was to investigate the characteristics of macular and optic disc parameters in children with amblyopic and nonamblyopic eyes, using fundus images under optical coherence tomography (OCT). 36 patients with anisometropic amblyopia were selected in the experimental group, and another 36 healthy volunteers were selected in the control group, OCT examinations were performed in all groups, and the mean diopter, mean corrected visual acuity (CVA), mean axial length, mean optic disc retinal nerve fiber layer (RNFL) thickness, and mean macular fovea thickness were recorded in the two groups. The results found that the average diopter of the patients in the control group and the experimental group was +2.30 ± 2.54 D and +5.51 ± 1.76 D, respectively. The average CVA was 0.86 ± 0.07 and 0.22 ± 0.16, respectively; the average eye axial length was 22.41 ± 1.20 mm and 21.11 ± 0.78 mm, respectively. As P < 0.05, the differences were statistically significant in the three indicators between the two groups. There was no significant difference between the two groups in the average thickness of the RNFL of the optic disc and the average thickness of the central fovea of macula (P > 0.05). There was some correlation among CVA, diopter, eye axial length, RNFL thickness, and average thickness of macular fovea, but the correlation was not significant. It was suggested that there were certain differences in the macular and optic disc parameters between amblyopic and nonamblyopic children, but the difference is little. Thereout, a certain objective basis was provided for the early detection and treatment of amblyopia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
General situation of patients in the two groups. # meant P < 0.05, as the differences were statistically significant.
Figure 2
Figure 2
Comparison of the average thickness and total retinal volume of the macular fovea between the two groups.
Figure 3
Figure 3
Comparison of macular parameters in patients with mild and moderate amblyopia in the experimental group.
Figure 4
Figure 4
Evaluation of the treatment effect on patients in the experimental group.
Figure 5
Figure 5
Comparison of macular parameters before and after treatment in the experimental group.
Figure 6
Figure 6
Comparison of the average thickness of the RNFL around the optic disc of patients between the two groups.
Figure 7
Figure 7
Comparison of optic disc parameters between the two groups.
Figure 8
Figure 8
Correlation analysis between indicators and foveal thickness in patients with amblyopia.
Figure 9
Figure 9
Correlation analysis between indicators and the thickness of RNFL around the optic disc in patients with amblyopia.
See this image and copyright information in PMC

References

    1. Gopal S. K. S., Kelkar J., Kelkar A., Pandit A. Simplified updates on the pathophysiology and recent developments in the treatment of amblyopia: a review. Indian Journal of Ophthalmology . 2019;67(9):1392–1399. doi: 10.4103/ijo.IJO_11_19. - DOI - PMC - PubMed
    1. Pineles S. L., Aakalu V. K., Hutchinson A. K., et al. Binocular treatment of amblyopia: a report by the American Academy of Ophthalmology. Ophthalmology . 2020;127(2):261–272. doi: 10.1016/j.ophtha.2019.08.024. - DOI - PubMed
    1. Balsor J. L., Jones D. G., Murphy K. M. Classification of visual cortex plasticity phenotypes following treatment for amblyopia. Neural Plasticity . 2019;2019:23. doi: 10.1155/2019/2564018.2564018 - DOI - PMC - PubMed
    1. Ryu W. Y., Lambert S. R. Incidence of strabismus and amblyopia among children initially diagnosed with pseudostrabismus using the optum data set. American Journal of Ophthalmology . 2020;211:98–104. doi: 10.1016/j.ajo.2019.10.036. - DOI - PMC - PubMed
    1. Chang J. W. Refractive error change and vision improvement in moderate to severe hyperopic amblyopia after spectacle correction: restarting the emmetropization process? PLoS One . 2017;12(4, article e0175780) doi: 10.1371/journal.pone.0175780. - DOI - PMC - PubMed