Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov 24:2:30-34.
doi: 10.1016/j.ijregi.2021.11.006. eCollection 2022 Mar.

Endoscopic and histopathological findings in adult dyspeptic patients, and their association with Helicobacter pylori infection in Dhaka, Bangladesh

Nusrat Noor Tanni  1 , Sharmeen Ahmed  2 , Shaheda Anwar  3 , Saifa Kismat  1 , Kakali Halder  4 , Maherun Nesa  5 , Farjana Binte Habib  6
Affiliations

Endoscopic and histopathological findings in adult dyspeptic patients, and their association with Helicobacter pylori infection in Dhaka, Bangladesh

Nusrat Noor Tanni et al. IJID Reg. .

Abstract

Objectives: Conventional upper-intestinal endoscopy is usually performed to diagnose Helicobacter pylori (H. pylori) associated diseases, using gastric mucosa from the biopsy. The objective of our study was to identify the prevalence of H. pylori and its relation with endoscopic findings and histopathological features in dyspeptic adult patients.

Methods: Gastroduodenal biopsy specimens were collected from 143 adult dyspeptic outpatients who attended the Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH), for endoscopy. H. pylori was identified by rapid urease test (RUT), ureC gene PCR, and histological staining (Giemsa).

Results: The study population was divided into H. pylori-positive cases (47; 32.9%) and H. pylori-negative cases (96; 67.1%), based on the case definitions used in the study. The highest rate of H. pylori infection was found in the 41-50 years age group (25.5%). Endoscopically, 101 (97.1%) dyspeptic patients had gastritis, with the majority of H. pylori infections found among histopathologically diagnosed duodenal ulcer patients. Endoscopic findings were significantly correlated with histological findings (p < 0.001).

Conclusion: Significant correlations between endoscopic and histopathological findings were observed. Early detection and prompt treatment of H. pylori infection are essential for the prevention of serious complications.

Keywords: Helicobacter pylori; PCR, Polymerase Chain Reaction; dyspepsia; endoscopy; histopathology; ureC gene PCR.

PubMed Disclaimer

References

    1. Aftab H, Yamaoka Y, Ahmed F, Khan AA, Subsomwong P, Miftahussurur M, et al. Validation of diagnostic tests and epidemiology of Helicobacter pylori infection in Bangladesh. The Journal of Infection in Developing Countries. 2018;12:305–312. doi: 10.3855/jidc.9841. - DOI - PubMed
    1. Alazmi WM, Siddique I, Alateeqi N, Al-Nakib B. Prevalence of Helicobacter pylori infection among new outpatients with dyspepsia in Kuwait. BMC Gastroenterology. 2010;10(1):1–4. doi: 10.1186/1471-230X-10-14. - DOI - PMC - PubMed
    1. Aminde JA, Dedino GA, Ngwasiri CA, Ombaku KS, Makon CA, Aminde LN. Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors. BMC infectious diseases. 2019;19(1):1–9. doi: 10.1186/s12879-019-3677-0. - DOI - PMC - PubMed
    1. Chen J, Bu XL, Wang QY, Hu PJ, Chen MH. Decreasing seroprevalence of Helicobacter pylori infection during 1993–2003 in Guangzhou, southern China. Helicobacter. 2007;12:164–169. doi: 10.1111/j.1523-5378.2007.00487.x. - DOI - PubMed
    1. Conroy RT, Siddiqi B. Dyspepsia. Primary Care: Clinics in Office Practice. 2007;34(1):99–108. doi: 10.1016/j.pop.2007.02.001. - DOI - PubMed

LinkOut - more resources