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. 2022 Jan 12:2:141-148.
doi: 10.1016/j.ijregi.2022.01.004. eCollection 2022 Mar.

Prevalence of tuberculosis (TB), including multi-drug-resistant and extensively-drug-resistant TB, and association with occupation in adults at Sirindhorn Hospital, Bangkok

Fingani Annie Mphande-Nyasulu  1 , Paisal Puengpipattrakul  1 , Mathuwadee Praipruksaphan  2 , Arada Keeree  2 , Karakade Ruanngean  2
Affiliations

Prevalence of tuberculosis (TB), including multi-drug-resistant and extensively-drug-resistant TB, and association with occupation in adults at Sirindhorn Hospital, Bangkok

Fingani Annie Mphande-Nyasulu et al. IJID Reg. .

Abstract

Background: Tuberculosis (TB) affects both child and adult populations worldwide.

Objectives: This retrospective study was conducted to survey the prevalence of TB and its association with patient occupation in an adult population diagnosed with TB at Sirindhorn Hospital in 2018.

Methods: Data were extracted from the medical records of 186 patients with TB, and prevalence and odds ratios were calculated.

Results: Pulmonary (83.3%) and extrapulmonary TB (17.7%) were observed among the cases. Overall, 70.4% of cases were male and 29.6% were female. Mono-drug-resistant TB, multi-drug-resistant TB and extensively-drug-resistant TB were observed in 2.72%, 4.1% and 0.68% of cases, respectively. Although not statistically significant, individuals with comorbidities had a 2.16-fold [95% confidence interval (CI) 0.33-13.98] higher risk of TB compared with those without comorbidities. Unemployed patients with TB were 4-fold (95% CI 0.82-19.42) more likely to have hypertension than employed patients or traders. The risk of TB among patients with human immunodeficiency virus (HIV) infection was 2.22-fold (95% CI 0.93-5.31) higher among females compared with males, and relapsed patients had a 0.92-fold (95% CI 0.19-4.47) lower risk of HIV infection as a comorbidity compared with new TB cases.

Conclusion: Patient occupation could play a role in the prevalence of TB among communities. The highest prevalence of TB was observed among unemployed subjects, and unemployed patients with TB were more likely to have hypertension as a comorbidity. Mapping the zones/areas of residence for patients with TB could assist in identifying TB hot spots, and could improve understanding of the drivers of the high TB burden and associated socio-economic factors. More studies are required to further understand the drivers that are leading to the high TB burden and the risks posed by occupations.

Keywords: Diabetes; Hypertension; Occupation (livelihood); Pulmonary tuberculosis; Socio-economic factors.

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Figures

Figure 1
Figure 1
Tuberculosis comorbidities among new and relapsed cases. CVA, cerebrovascular accident; COPD, chronic obstructive pulmonary disease; HBV, hepatitis B virus infection; DLP, dyslipidaemia; HIV, human immunodeficiency virus infection; DM, diabetes mellitus; HT, hypertension.
Figure 2
Figure 2
Distribution of tuberculosis (TB) cases by city/town of residence attending Sirindhorn Hospital in 2018. DR-TB, mono-drug-resistant TB; MDR-TB, multi-drug-resistant TB; XDR-TB, extensively-drug-resistant TB.
Figure 3
Figure 3
Occupations of tuberculosis (TB patients) attending Sirindhorn Hospital in 2018.
See this image and copyright information in PMC

References

    1. Aekplakorn W, Chariyalertsak S, Kessomboon P, Assanangkornchai S, Taneepanichskul S, Putwatana P. Prevalence of diabetes and relationship with socioeconomic status in the Thai population: national health examination survey, 2004–2014. J Diabetes Res. 2018;2018 - PMC - PubMed
    1. Aungkulanon S, McCarron M, Lertiendumrong J, Olsen SJ, Bundhamcharoen K. Infectious disease mortality rates, Thailand, 1958–2009. Emerg Infect Dis. 2012;18:1794–1801. - PMC - PubMed
    1. Aungkulanon S, Tangcharoensathien V, Shibuya K, Bundhamcharoen K, Chongsuvivatwong V. Area-level socioeconomic deprivation and mortality differentials in Thailand: results from principal component analysis and cluster analysis. Int J Equity Health. 2017;16:1–12. - PMC - PubMed
    1. Cadena J, Rathinavelu S, Lopez-Alvarenga JC, Restrepo BI. The re-emerging association between tuberculosis and diabetes: lessons from past centuries. Tuberculosis. 2019;116(Suppl):S89–S97. - PMC - PubMed
    1. Dean AS, Zignol M, Falzon D, Getahun H, Floyd K. HIV and multidrug-resistant tuberculosis: overlapping epidemics. Eur Respir J. 2014;44:251–254. - PubMed

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