Prevalence of H. pylori among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy

doi:10.1016/j.ijregi.2022.01.007

. 2022 Jan 19:2:169-174.

doi: 10.1016/j.ijregi.2022.01.007. eCollection 2022 Mar.

Prevalence of H. pylori among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy

Million Getachew Mesfun^{1

2

3}, Smaranda Gliga¹, Andre Fuchs^{2

4}, Hans Martin Orth^{1

2}, Andreas Schönfeld^{2

5}, Tom Luedde^{1

2}, Torsten Feldt^{1

2}

Affiliations

¹ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany.
² Hirsch Institute of Tropical Medicine, Asella, Ethiopia.
³ College of Health Sciences, Arsi University, Asella, Ethiopia.
⁴ Internal Medicine III - Gastroenterology and Infectious Diseases, University Hospital of Augsburg, Augsburg, Germany.
⁵ Department of Infectious Diseases, West German Centre of Infectious Diseases, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

PMID: 35757079
PMCID: PMC9216691
DOI: 10.1016/j.ijregi.2022.01.007

Prevalence of H. pylori among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy

Million Getachew Mesfun et al. IJID Reg. 2022.

. 2022 Jan 19:2:169-174.

doi: 10.1016/j.ijregi.2022.01.007. eCollection 2022 Mar.

Authors

Million Getachew Mesfun^{1

2

3}, Smaranda Gliga¹, Andre Fuchs^{2

4}, Hans Martin Orth^{1

2}, Andreas Schönfeld^{2

5}, Tom Luedde^{1

2}, Torsten Feldt^{1

2}

Affiliations

¹ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany.
² Hirsch Institute of Tropical Medicine, Asella, Ethiopia.
³ College of Health Sciences, Arsi University, Asella, Ethiopia.
⁴ Internal Medicine III - Gastroenterology and Infectious Diseases, University Hospital of Augsburg, Augsburg, Germany.
⁵ Department of Infectious Diseases, West German Centre of Infectious Diseases, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

PMID: 35757079
PMCID: PMC9216691
DOI: 10.1016/j.ijregi.2022.01.007

Abstract

Objectives: Helicobacter pylori is a widespread pathogen and major contributor to dyspeptic disease and gastric cancer. Although the interaction between HIV and H. pylori infection is not well investigated, previous studies have suggested a decreased prevalence of H. pylori and limited efficacy of eradication therapy in HIV-positive individuals. Therefore, the objectives of this study were to describe the prevalence of H. pylori infection according to HIV status and analyze the efficacy of eradication therapy in Ethiopia.

Methods: A prospective, randomized, interventional study was performed involving HIV-positive and negative participants presenting to the Asella Referral and Teaching Hospital in Central Ethiopia between March and June 2017. A stool antigen test was used as a screening tool for H. pylori infection. Randomly selected patients received triple eradication therapy.

Results: The cumulative H. pylori prevalence was 77.3% (392/507): 78.8% (241/306) among HIV-positive individuals versus 75.1% (151/201) among HIV-negative individuals (P = 0.386). Twenty-five HIV-positive and 26 HIV-negative H. pylori-infected participants were randomized to receive standard triple therapy; three of them were lost to follow-up (one HIV-positive, two HIV-negative). The total eradication rate was 50.0%: 62.5% (15/24) among those HIV-negative versus 37.5% (9/24) among those HIV-positive [Au?1].

Conclusions: A high prevalence of H. pylori was observed among HIV-positive and negative individuals in Central Ethiopia. The efficacy of eradication therapy was low, with a trend towards lower efficacy in HIV-infected individuals.

Keywords: Africa; Antimicrobial resistance; Helicobacter; Oromia; Sub-Saharan Africa.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Study design flow chart. VCT: voluntary counseling and HIV testing clinic; n: number.

See this image and copyright information in PMC

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References

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1. Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, WA Al-Soud, Wadström T, Kassa E. Prevalence of Helicobacter pylori infection among adult dyspeptic patients in Ethiopia. Ann Trop Med Parasitol. 2004;98(2):181–189. doi: 10.1179/000349804225003190. - DOI - PubMed
1. Awuku YA, Simpong DL, Alhassan IK, Tuoyire DA, Afaa T, Adu P. Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa. BMC Public Health. 2017;17:360. doi: 10.1186/s12889-017-4274-z. - DOI - PMC - PubMed
1. Bello AK, Umar AB, Borodo MM. Prevalence and risk factors for Helicobacter pylori infection in gastroduodenal diseases in Kano, Nigeria. Afr J Med Health Sci. 2018;17:41–46. doi: 10.5897/AJMHS.9000010. - DOI
1. Ceschi A, Curkovic I, Kirchheiner J, Kullak-Ublick GA, Jetter A. Arzneimittel interaktionen mit antiretroviralen Medikamenten [Interactions with antiretroviral drugs] Internist (Berl) 2010;51(1):94–99. doi: 10.1007/s00108-009-2528-2. - DOI - PubMed

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[1] Asrat D, Kassa E, Mengistu Y, Nilsson I, Wadström T. Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2004;42(2):79–85. PMID: 16895024. - PubMed

[2] Asrat D, Kassa E, Mengistu Y, Nilsson I, Wadström T. Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2004;42(2):79–85. PMID: 16895024. - PubMed

[3] Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, WA Al-Soud, Wadström T, Kassa E. Prevalence of Helicobacter pylori infection among adult dyspeptic patients in Ethiopia. Ann Trop Med Parasitol. 2004;98(2):181–189. doi: 10.1179/000349804225003190. - DOI - PubMed

[4] Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, WA Al-Soud, Wadström T, Kassa E. Prevalence of Helicobacter pylori infection among adult dyspeptic patients in Ethiopia. Ann Trop Med Parasitol. 2004;98(2):181–189. doi: 10.1179/000349804225003190. - DOI - PubMed

[5] Awuku YA, Simpong DL, Alhassan IK, Tuoyire DA, Afaa T, Adu P. Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa. BMC Public Health. 2017;17:360. doi: 10.1186/s12889-017-4274-z. - DOI - PMC - PubMed

[6] Awuku YA, Simpong DL, Alhassan IK, Tuoyire DA, Afaa T, Adu P. Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa. BMC Public Health. 2017;17:360. doi: 10.1186/s12889-017-4274-z. - DOI - PMC - PubMed

[7] Bello AK, Umar AB, Borodo MM. Prevalence and risk factors for Helicobacter pylori infection in gastroduodenal diseases in Kano, Nigeria. Afr J Med Health Sci. 2018;17:41–46. doi: 10.5897/AJMHS.9000010. - DOI

[8] Bello AK, Umar AB, Borodo MM. Prevalence and risk factors for Helicobacter pylori infection in gastroduodenal diseases in Kano, Nigeria. Afr J Med Health Sci. 2018;17:41–46. doi: 10.5897/AJMHS.9000010. - DOI

[9] Ceschi A, Curkovic I, Kirchheiner J, Kullak-Ublick GA, Jetter A. Arzneimittel interaktionen mit antiretroviralen Medikamenten [Interactions with antiretroviral drugs] Internist (Berl) 2010;51(1):94–99. doi: 10.1007/s00108-009-2528-2. - DOI - PubMed

[10] Ceschi A, Curkovic I, Kirchheiner J, Kullak-Ublick GA, Jetter A. Arzneimittel interaktionen mit antiretroviralen Medikamenten [Interactions with antiretroviral drugs] Internist (Berl) 2010;51(1):94–99. doi: 10.1007/s00108-009-2528-2. - DOI - PubMed

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Prevalence of H. pylori among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy

Affiliations

Prevalence of H. pylori among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Abstract

Conflict of interest statement

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