STRUCTURAL AND FUNCTIONAL FEATURES OF PERIPHERAL BLOOD ERYTHROCYTES AND ANTIOXIDANT PROTECTION ENZYMES IN PATIENTS WITH MULTIPLE SCLEROSIS

Abstract

Objective: The aim: The aim of this work is to study the structural and functional features of peripheral blood erythrocytes and antioxidant defense enzymes in patients with multiple sclerosis, depending on its clinical forms and the stage of development of the pathological process.

Patients and methods: Materials and methods: The state of the processes of lipid peroxidation and the antioxidant defense system in 62 patients with multiple sclerosis was studied. The influence of these processes on the clinical manifestations of multiple sclerosis is shown.

Results: Results: It has been shown that in multiple sclerosis, the erythrocyte superoxide dismutase / catalase enzyme system is characterized by the phenomenon of cross-regulation of activity, which is reflected in a negative correlation between enzyme activities and is associated with the appearance of irreversibly altered forms of erythrocytes in the general bloodstream.

Conclusion: Conclusions: Based on the analysis of the dynamics of laboratory parameters, the pathogenetic significance of membrane-destabilizing processes in peripheral blood erythrocytes of patients with multiple sclerosis was proved.

Keywords: antioxidant defense enzymes; erythrocytes; multiple sclerosis.