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. 2022;66(4):489-497.
doi: 10.20945/2359-3997000000489. Epub 2022 Jun 23.

Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity - A cross sectional study

Nelson do Rosário Caldas  1 , Valeria Bender Braulio  2 , Marco Antônio Alves Brasil  3 , Valeria Cristina Soares Furtado  4 , Denise Pires de Carvalho  5 , Ervin Michelstaedter Cotrik  3 , Joana Rodrigues Dantas  2 , Lenita Zajdenverg  2
Affiliations

Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity - A cross sectional study

Nelson do Rosário Caldas et al. Arch Endocrinol Metab. 2022.

Abstract

Introduction: Binge eating disorder (BED) is the most prevalent eating disorder in individuals with obesity. Its association with factors that control hunger and satiety has not yet been elucidated. We evaluated whether levels of inflammatory markers, frequency of psychiatric comorbidities, and appetite-related hormones levels differ between individuals with obesity with and without BED.

Subjects and methods: The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-5 - Clinician Version (SCID-5-CV), Binge Eating Scale, and Hospital Anxiety and Depression Scale were evaluated in 39 individuals with obesity. Plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) were measured.

Results: Individuals of the BED group exhibited significantly higher percentages of altered eating patterns (hyperphagia, bingeing, post-dinner eating, feeling "stuffed", and emotional eating), higher depressive symptom scores and levels of leptin, CRP, and TNF-α, compared to those from the non-BED group. Logistic regression showed that BED was independently associated with depressive symptoms and CRP levels.

Conclusion: Individuals with obesity and BED showed greater psychiatric comorbidity, worse eating patterns and worse inflammatory profile than those without BED. BED should be assessed as an indicator of clinical severity in patients with obesity.

Keywords: Binge eating disorder; depression; inflammation; leptin; obesity.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Study population flowchart diagram.
EDNOS: eating disorder not otherwise specified. *Women in postmenopause (n = 57); diabetes (n = 22); hypo- or hyperthyroidism (n = 21); inflammatory diseases (cardiomyopathies, systemic lupus erythematosus, endometriosis, cancer, multiple sclerosis, venous thrombosis, systemic arterial hypertension, n = 20); use of psychotropics (neuroleptics, antidepressants and mood stabilizers, n = 12); smoking (n = 2); use of corticosteroids (n = 1).
Figure 2
Figure 2. Eating patterns in non-BED and BED obese patients.
The asterisks indicate values of p obtained by Pearson´s chi-squared test.
See this image and copyright information in PMC

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