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. 2022 Oct 3;75(Suppl 2):S155-S158.
doi: 10.1093/cid/ciac526.

Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021

Heidi L Moline  1   2 , Amelia Keaton  1 , Whitney Rice  3 , Jasmine Varghese  1 , Li Deng  1 , Ansley Waters  4   5 , Anna Barringer  3 , Devonne Winston  3 , Virgie Fields  5 , Kara Jacobs Slifka  1 , Jennifer R Verani  1 , Stephanie J Schrag  1 , John Jernigan  1 , Jacqueline E Tate  1 , Katherine E Fleming-Dutra  1
Affiliations

Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021

Heidi L Moline et al. Clin Infect Dis. .

Abstract

In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval: 25-84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.

Keywords: SARS-CoV-2; skilled nursing facility; vaccine effectiveness.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Supplementary concepts