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Observational Study
. 2022 Aug 1;182(8):805-813.
doi: 10.1001/jamainternmed.2022.2291.

Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis

Hallie C Prescott  1   2 , Sarah Seelye  2 , Xiao Qing Wang  1 , Cainnear K Hogan  2 , Joshua T Smith  3 , Patricia Kipnis  3 , Fernando Barreda  3 , John P Donnelly  4 , Jason M Pogue  5 , Theodore J Iwashyna  1   2 , Makoto M Jones  6   7 , Vincent X Liu  3
Affiliations
Observational Study

Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis

Hallie C Prescott et al. JAMA Intern Med. .

Abstract

Importance: Some experts have cautioned that national and health system emphasis on rapid administration of antimicrobials for sepsis may increase overall antimicrobial use even among patients without sepsis.

Objective: To assess whether temporal changes in antimicrobial timing for sepsis are associated with increasing antimicrobial use, days of therapy, or broadness of antimicrobial coverage among all hospitalized patients at risk for sepsis.

Design, setting, and participants: This is an observational cohort study of hospitalized patients at 152 hospitals in 2 health care systems during 2013 to 2018, admitted via the emergency department with 2 or more systemic inflammatory response syndrome (SIRS) criteria. Data analysis was performed from June 10, 2021, to March 22, 2022.

Exposures: Hospital-level temporal trends in time to first antimicrobial administration.

Outcomes: Antimicrobial outcomes included antimicrobial use, days of therapy, and broadness of antibacterial coverage. Clinical outcomes included in-hospital mortality, 30-day mortality, length of hospitalization, and new multidrug-resistant (MDR) organism culture positivity.

Results: Among 1 559 523 patients admitted to the hospital via the emergency department with 2 or more SIRS criteria (1 269 998 male patients [81.4%]; median [IQR] age, 67 [59-77] years), 273 255 (17.5%) met objective criteria for sepsis. In multivariable models adjusted for patient characteristics, the adjusted median (IQR) time to first antimicrobial administration to patients with sepsis decreased by 37 minutes, from 4.7 (4.1-5.3) hours in 2013 to 3.9 (3.6-4.4) hours in 2018, although the slope of decrease varied across hospitals. During the same period, antimicrobial use within 48 hours, days of antimicrobial therapy, and receipt of broad-spectrum coverage decreased among the broader cohort of patients with SIRS. In-hospital mortality, 30-day mortality, length of hospitalization, new MDR culture positivity, and new MDR blood culture positivity decreased over the study period among both patients with sepsis and those with SIRS. When examining hospital-specific trends, decreases in antimicrobial use, days of therapy, and broadness of antibacterial coverage for patients with SIRS did not differ by hospital antimicrobial timing trend for sepsis. Overall, there was no evidence that accelerating antimicrobial timing for sepsis was associated with increasing antimicrobial use or impaired antimicrobial stewardship.

Conclusions and relevance: In this multihospital cohort study, the time to first antimicrobial for sepsis decreased over time, but this trend was not associated with increasing antimicrobial use, days of therapy, or broadness of antimicrobial coverage among the broader population at-risk for sepsis, which suggests that shortening the time to antibiotics for sepsis is feasible without leading to indiscriminate antimicrobial use.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Prescott reported receiving grants from the US Department of Veterans Affairs and Blue Cross Blue Shield of Michigan outside the submitted work, serving on the Surviving Sepsis Campaign Guidelines Panel, and serving as physician lead for a Michigan statewide sepsis collaborative. Dr Donnelly reported receiving grants from the National Institutes of Health, National Heart, Lung, and Blood Institute (K12 K12 Scholar) during the conduct of the study and receiving personal fees from American College of Emergency Physicians and Annals of Emergency Medicine outside the submitted work. Dr Jones reported receiving grants from the Department of Veterans Affairs outside the submitted work. Dr Liu reported receiving grants from the National Institutes of Health (GM128672) during the conduct of the study. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Temporal Trends in Time to First Antimicrobial Administration Among Patients With Sepsis, by Hospital
Orange dots indicate median time to first antimicrobial by year; blue lines denote temporal trend in median time to first antimicrobial per hospital. Median time to first antimicrobial, after adjustment for patient characteristics, decreased by 7.3 minutes per year (from a median [IQR] of 4.7 [4.1-5.3] hours in 2013 to 3.9 [3.6-4.4] hours in 2018).
Figure 2.
Figure 2.. Association Between Hospital-Level Temporal Trends in Antimicrobial Timing for Sepsis and Hospital-Level Trends in Antimicrobial Use, Days of Therapy, and Broadness of Antibacterial Coverage
In each scatterplot, the exposure (annual change in time to first antimicrobial among hospitalized patients with sepsis) is on the x-axis, and the outcome (annual change in antimicrobial use, days of therapy, and broadness of coverage) is on the y-axis. Each dot represents an individual hospital. The orange line shows the fitted association between temporal trends, estimated from a robust regression in which hospitals were weighted according to number of hospitalized patients. The line at 0 shows no change. The Spearman correlation between temporal trends and the slope from the robust regression are shown in each panel. Broadness of antibacterial coverage was measured using Spectrum Score (range, 0-64, in which higher scores represent broader coverage). There was no association between hospital temporal trends in antimicrobial timing among patients with sepsis and trends in antimicrobial use (A), days of antimicrobial therapy (B), or broadness of antibacterial coverage (C).
See this image and copyright information in PMC

References

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