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Multicenter Study
. 2022 Nov;42(11):1458-1464.
doi: 10.1038/s41372-022-01433-2. Epub 2022 Jun 27.

Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort

Irfan Ahmad  1 , Muralidhar H Premkumar  2 , Amy B Hair  2 , Kevin M Sullivan  3 , Isabella Zaniletti  4 , Jotishna Sharma  5 , Sujir Pritha Nayak  6 , Kristina M Reber  2 , Michael Padula  7 , Beverly Brozanski  8 , Robert DiGeronimo  9 , Toby Debra Yanowitz  10 ; Children’s Hospitals Neonatal Consortium NEC Focus Group
Collaborators, Affiliations
Multicenter Study

Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort

Irfan Ahmad et al. J Perinatol. 2022 Nov.

Abstract

Objectives: To evaluate variability in antibiotic duration for necrotizing enterocolitis (NEC) and associated clinical outcomes.

Study design: Five-hundred ninety-one infants with NEC (315 medical; 276 surgical) were included from 22 centers participating in Children's Hospitals Neonatal Consortium (CHNC). Multivariable analyses were used to determine predictors of variability in time to full feeds (TFF) and length of stay (LOS).

Results: Median (IQR) antibiotic duration was 12 (9, 17) days for medical and 17 (14, 21) days for surgical NEC. Wide variability in antibiotic use existed both within and among centers. Duration of antibiotic therapy was associated with longer TFF in both medical (OR 1.04, 95% CI [1.01, 1.05], p < 0.001) and surgical NEC (OR 1.02 [1, 1.03] p = 0.046); and with longer LOS in medical (OR 1.03 [1.02, 1.04], p < 0.001) and surgical NEC (OR 1.01 [1.01, 1.02], p = 0.002).

Conclusion: Antibiotic duration for both medical and surgical NEC remains variable within and among high level NICUs.

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References

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