The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi^#^{1

2

3

4

5

6}, Bo Liu^{7

8

9}, Xinquan Wang^{10

11}, Linqi Zhang^#^{12

13

14

15}

Affiliations

¹ Tsinghua-Peking Center for Life Sciences, Beijing, China. qihai@tsinghua.edu.cn.
² Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
³ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁴ NexVac Research Center, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁵ Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China. qihai@tsinghua.edu.cn.
⁶ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁷ Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁸ Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China.
⁹ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
¹⁰ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.
¹¹ School of Life Sciences, Tsinghua University, Beijing, China.
¹² Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹³ NexVac Research Center, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁴ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁵ Comprehensive AIDS Research Center, Center for Global Health and Infectious Diseases, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.

^# Contributed equally.

PMID: 35761083
DOI: 10.1038/s41590-022-01248-5

Review

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi et al. Nat Immunol. 2022 Jul.

. 2022 Jul;23(7):1008-1020.

doi: 10.1038/s41590-022-01248-5. Epub 2022 Jun 27.

Authors

Hai Qi^#^{1

2

3

4

5

6}, Bo Liu^{7

8

9}, Xinquan Wang^{10

11}, Linqi Zhang^#^{12

13

14

15}

Affiliations

¹ Tsinghua-Peking Center for Life Sciences, Beijing, China. qihai@tsinghua.edu.cn.
² Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
³ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁴ NexVac Research Center, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁵ Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China. qihai@tsinghua.edu.cn.
⁶ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁷ Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁸ Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China.
⁹ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
¹⁰ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.
¹¹ School of Life Sciences, Tsinghua University, Beijing, China.
¹² Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹³ NexVac Research Center, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁴ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁵ Comprehensive AIDS Research Center, Center for Global Health and Infectious Diseases, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.

^# Contributed equally.

PMID: 35761083
DOI: 10.1038/s41590-022-01248-5

Abstract

Two and a half years into the COVID-19 pandemic, we have gained many insights into the human antibody response to the causative SARS-CoV-2 virus. In this Review, we summarize key observations of humoral immune responses in people with COVID-19, discuss key features of infection- and vaccine-induced neutralizing antibodies, and consider vaccine designs for inducing antibodies that are broadly protective against different variants of the SARS-CoV-2 virus.

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References

1. Carvalho, T., Krammer, F. & Iwasaki, A. The first 12 months of COVID-19: a timeline of immunological insights. Nat. Rev. Immunol. 21, 245–256 (2021). - PubMed - PMC - DOI
1. Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H. & Tham, T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol. Head. Neck Surg. 163, 3–11 (2020). - PubMed - DOI
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1. Jose, R. J. & Manuel, A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir. Med 8, e46–e47 (2020). - PubMed - DOI

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The humoral response and antibodies against SARS-CoV-2 infection

Affiliations

The humoral response and antibodies against SARS-CoV-2 infection

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous