Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 May 1;25(3):209-215.
doi: 10.1097/MCO.0000000000000834. Epub 2022 Mar 3.

Extracellular vesicles in human milk

Affiliations
Review

Extracellular vesicles in human milk

Regina Golan-Gerstl et al. Curr Opin Clin Nutr Metab Care. .

Abstract

Purpose of review: Milk-derived extracellular vesicles (MDEVs) are nanovesicles that carry microRNA (miRNA) DNA, RNA, proteins and lipids. MDEVs have a potential of therapeutic targets, based on their properties and cargo profile. The present review summarizes recent studies on MDEVs, their cargo and potential role in mammalian development.

Recent findings: The detailed characterization of their miRNA cargo leads to the conclusion of their potential importance in the regulation of gene expression, immune function, development and infant growth.While their miRNAs are important regulatory elements and their profile expression was characterized in various mammalian milk sources, little is known about their effect on infant health and development. MiRNA activity in breast milk is likely influenced by the overall ecosystem of the early environment, including maternal characteristics, behaviors, and health.

Summary: MDEVs may have an important role in early child development and infant future health. Understanding benefits of MDEVs characteristics have potential role on gut maturation, immune system development and the prevention of metabolic disorders.

PubMed Disclaimer

References

    1. Théry C, Witwer KW, Aikawa E. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018; 7:1535750doi: 10.1080/20013078.2018.1535750. - DOI
    1. Yu Y, Zhou Y, Di C, et al. Increased airway epithelial cell–derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding. J Cell Mol Med 2021; 25:8850–8862.
    1. Qi Z, Xue Q, Wang H, et al. Serum CD203c+ extracellular vesicle serves as a novel diagnostic and prognostic biomarker for succinylated gelatin induced perioperative hypersensitive reaction. Front Immunol 2021; 12:732209.
    1. Małys MS, Aigner C, Schulz SM, et al. Isolation of Small Extracellular Vesicles from Human Sera. Int J Mol Sci 2021; 22:4653.
    1. García-Flores M, Sánchez-López CM, Ramírez-Calvo M, et al. Isolation and characterization of urine microvesicles from prostate cancer patients: different approaches, different visions. BMC Urol 2021; 21:137.