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. 2022 Oct;46(10):e14294.
doi: 10.1111/jfbc.14294. Epub 2022 Jun 28.

Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats

Nathalia da Silva Costa  1 , Patricia Pereira Almeida  1 , Beatriz Oliveira Da Cruz  1 , Michele Lima Brito  2 , Johnatas Maldonado-Campos  3 , Agatha Cristie Menezes  1 , Mariana Sarto Figueiredo  4 , D' Angelo Carlo Magliano  1 , Aline D'Avila Pereira  5 , Milena Barcza Stockler-Pinto  1   4
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Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats

Nathalia da Silva Costa et al. J Food Biochem. 2022 Oct.

Abstract

Oxidative stress, adipose tissue, and bone compartments can be disturbed in chronic diseases. Non-pharmacological strategies, such as Brazil nuts (BNs), can improve these parameters. This study evaluated the effects of BN supplementation at different concentrations on body composition, lipid profile, and peroxidation in healthy rats. Male Wistar rats were divided into three groups: control (CT), Brazil nut 5% (BN5), and Brazil nut 10% (BN10) groups. Body composition, brown adipose tissue (BAT), plasma lipid peroxidation, and lipid profile were evaluated in the three groups. The BN5 group showed an improvement in all bone parameters compared with that of the CT group (p < .0001). The BN5 and BN10 groups showed reduced plasma lipid peroxidation compared with that of the CT group (p = .0009), whereas the BN10 group presented lower BAT lipid peroxidation than that of the other groups (p = .01). High-density lipoprotein-cholesterol (HDL-c) levels were higher in the BN5 group than in the CT group (p = .01). Conclusively, the use of BNs in a controlled manner promoted improvement in bone parameters, HDL-c levels, and lipid peroxidation in healthy rats. PRACTICAL APPLICATIONS: Nuts has been included in the diet because of their versatility, acceptance, and easy access. Among them, Brazil nut (BN) is considered one of the major known food sources of selenium as well as a source of fibers, unsaturated fatty acids, and phenolic compounds. Studies have shown that BN supplementation is effective in reducing oxidative stress, inflammation, lipid peroxidation, and selenium deficiency when used as a non-pharmacological strategy in experimental models of chronic diseases and in clinical trials. The present study showed that controlled administration of BN improved bone parameters, high-density lipoprotein-cholesterol levels, and lipid peroxidation in healthy rats. Therefore, BN is a promising non-pharmacological agent for the prevention of the onset of chronic non-communicable diseases.

Keywords: Brazil nut; body composition; bone parameters; lipid peroxidation; lipid profile.

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