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. 2022 Dec;61(8):3943-3960.
doi: 10.1007/s00394-022-02938-4. Epub 2022 Jun 28.

Association between dietary intake networks identified through a Gaussian graphical model and the risk of cancer: a prospective cohort study

Madhawa Gunathilake #  1 , Tung Hoang #  1 , Jeonghee Lee  1 , Jeongseon Kim  2
Affiliations

Association between dietary intake networks identified through a Gaussian graphical model and the risk of cancer: a prospective cohort study

Madhawa Gunathilake et al. Eur J Nutr. 2022 Dec.

Abstract

Purpose: In this study, we aimed to investigate the association between dietary communities identified by a Gaussian graphical model (GGM) and cancer risk.

Methods: We performed GGM to identify the dietary communities in a Korean population. GGM-derived communities were then scored and investigated for their association with cancer incidence in the entire population as well as in the 1:1 age- and sex-matched subgroup using a Cox proportional hazards model. In the sensitivity analysis, GGM-derived communities were compared to dietary patterns (DPs) that were identified by principal component analysis (PCA) and reduced rank regression (RRR).

Results: During a median time to follow-up of 6.6 years, 397 cancer cases were newly diagnosed. The GGM identified 17 and 16 dietary communities for the total and matched populations, respectively. For each one-unit increase in the standard deviation of the community-specific score of the community that was composed of dairy products and bread, there was a reduced risk of cancer according to the fully adjusted model (HR: 0.80, 95% CI: 0.66-0.96). In the matched population, the third tertile of the community-specific score of the community composed of poultry, seafood, bread, cakes and sweets, and meat by-products showed a significantly reduced risk of cancer compared to that of the lowest tertile in the fully adjusted model (HR: 0.66, 95% CI: 0.50-0.86, p-trend = 0.002).

Conclusion: We found that the GGM-identified community composed of dairy products and bread showed a reduced risk of cancer. Further population-based prospective studies should be conducted to examine possible associations of dietary intake and specific cancer types.

Keywords: Cancer incidence; Dietary patterns; Gaussian graphical model; Principal component analysis; Reduced rank regression.

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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424 - PubMed - DOI
    1. https://gco.iarc.fr/ Accessed Apr. 10 2022.
    1. Hong S, Won YJ, Lee JJ, Jung KW, Kong HJ, Im JS, Seo HG (2021) Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2018. Cancer Res Treat 53(2):301–315 - PubMed - PMC - DOI
    1. Woo HD, Park S, Oh K, Kim HJ, Shin HR, Moon HK, Kim J (2014) Diet and cancer risk in the Korean population: a meta-analysis. Asian Pac J Cancer Prev 15(19):8509–8519 - PubMed - DOI
    1. Organization WH (2003) Food based dietayr guidelines in the WHO Europena region . Geneva: WHO http://www.euro.who.int/__data/assets/pdf_file/0017/150083/E79832.pdf Accessed Apr. 10 2022.

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