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. 2022 Jun 28;204(7):436.
doi: 10.1007/s00203-022-03053-y.

Effects of Sporisorium reiliana polysaccharides and Phoenix dactylifera monosaccharides on the gut microbiota and serum metabolism in mice with fructose-induced hyperuricemia

Ziyan Wang #  1   2   3 , Zhixuan Zhang #  1   2   3 , Chenyang Lu  1   2   3 , Jun Zhou  1   2   3 , Zhonghua Wang  4 , Jiaojiao Han  5   6   7 , Xiurong Su  8   9   10
Affiliations

Effects of Sporisorium reiliana polysaccharides and Phoenix dactylifera monosaccharides on the gut microbiota and serum metabolism in mice with fructose-induced hyperuricemia

Ziyan Wang et al. Arch Microbiol. .

Abstract

In recent decades, the prevalence of hyperuricemia has increased, and dietary fructose is an important risk factor for the development of this disease. This study investigated and compared the effects of Sphacelotheca reiliana polysaccharides and Phoenix dactylifera monosaccharides on a series of physiological and biochemical indicators and on the metagenomes and serum metabolites in mice with hyperuricemia caused by a high-fructose diet. S. reiliana polysaccharides inhibited uric acid biosynthesis and promoted uric acid excretion, thereby alleviating the hyperuricemia phenotype. In addition, hyperuricemia was closely related to the gut microbiota. After treatment with S. reiliana polysaccharides, the abundances of Bacteroidetes and Proteobacteria in the mouse intestines were decreased, the expression of genes involved in glycolysis/gluconeogenesis metabolic pathways and purine metabolism was downregulated, and the dysfunction of the gut microbiota was alleviated. With regard to serum metabolism, the abundance of hippuric acid, uridine, kynurenic acid, propionic acid and arachidonoyl decreased, and the abundances of serum metabolites in inflammatory pathways involved in kidney injury and gout, such as bile acid metabolism, purine metabolism and tryptophan metabolism pathways, decreased. P. dactylifera monosaccharides aggravated hyperuricemia. This research provides a valuable reference for the development of sugar applications.

Keywords: Fructose; Hyperuricemic; Metabolomics; Metagenomics; Phoenix dactylifera monosaccharide; Sphacelotheca reiliana polysaccharide.

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References

    1. Abdelhak M, Guendez E, Eugene K, Panagiotis K (2005) Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chem 89(3):411–420
    1. Ahmad A, Yang W, Chen G, Shafiq M, Javed S, Ali Zaidi SS, Shahid R, Liu C, Bokhari H (2019) Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals. PLoS ONE 14(12):1–15
    1. Assirey EAR (2015) Nutritional composition of fruit of 10 date palm (Phoenix dactylifera L.) cultivars grown in Saudi Arabia. J Taibah Univ Sci 9(1):75–79
    1. Calvani R, Miccheli A, Capuani G, Tomassini MA, Puccetti C, Delfini M, Iaconelli A, Nanni G, Mingrone G (2010) Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. Int J Obes (lond) 34(6):1095–1098
    1. Dasilva G, Pazos M, García E, Pérez J, Torres JL, Giralt M, Nogués MR, Medina I (2016) Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of metabolic syndrome using SHROB rats as a model. Food Chem 205:196–203 - PubMed

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